Conversations covering the Manufacturing sector focussed on the Cambridgeshire and Peterborough Region.
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Smart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up for Busy Scientists
David Brühlmann: Biotech Entrepreneur & Cell Culture Technology Innovation Aficionado
The Go-to Podcast for Biotech Scientists Who Want to Master Bioprocess CMC Development and Manufacturing of Biologics. Do you want to simplify bioprocessing so that you can scale with confidence and reduce time to market? Are you sick of feeling overwhelmed by the complexity and guesswork of biologics drug development? Do you wish you had more time to enjoy the beauty of science, without worrying about failing your cell culture process development and commercialization? There’s a way to simp ...
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47: Mastering Process Economics: Driving Down Costs in Antibody Production w/ Brian Kelley - Part 1
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Join us in this enlightening episode as we explore process economics with industry expert Brian Kelley. He is the Senior Vice President of Process Development at VIR Biotechnology. Unraveling the mysteries of cost management in antibody therapeutics, Brian sheds light on the intricate challenges faced by biotech scientists and engineers. Key Highli…
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46: From Lab to Table: The Science Behind Cultivated Meat w/ Petra Hanga - Part 2
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Dive into the future of food with our latest episode, "From Lab to Table: The Science Behind Cultivated Meat." With our guest, Petra Hanga, a Lecturer in Biochemical Engineering at University College London and Chief Scientific Officer of Quest Meat Ltd., we unravel the secrets behind this groundbreaking technology. Key highlights: 1. Discover how …
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45: From Lab to Table: The Science Behind Cultivated Meat w/ Petra Hanga - Part 1
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Dive into the fascinating world of cultivated meat with our guest, Petra Hanga, Lecturer in Biochemical Engineering – Cellular Agriculture at University College London and the Chief Scientific Officer of Quest Meat Ltd. In this episode, Petra sheds light on the intricacies of developing cultivated meat and reveals the key hurdles biotech scientists…
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44: Mastering the Art and Science of Glycan Engineering in Drug Development w/ Henning von Horsten - Part 2
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Does uncovering the secrets of glycan engineering feel like navigating a maze of molecular complexity? In this captivating continuation of our exploration into the world of glycan engineering, we delve deeper into groundbreaking innovations and the crucial role of analytics in ensuring consistent quality. Henning von Horsten, Professor of Industria…
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43: Mastering the Art and Science of Glycan Engineering in Drug Development w/ Henning von Horsten - Part 1
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Does unlocking the secrets of glycan engineering seem like navigating a labyrinth of molecular complexity? In this episode, we delve into the pivotal role of glycans as critical quality attributes (CQAs) in biotherapeutics. Henning von Horsten, Professor of Industrial Bioengineering at HTW Berlin (University of Applied Sciences in Berlin), sheds li…
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42: Revealing the Disciplined Pursuit of Less in Bioprocessing - Part 2
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Hey, fellow scientists! Do you find yourself buried under an avalanche of tasks, unsure which one truly matters? If you're tired of the chaos and want to reclaim control of your time and energy, stick around. Today, we're unlocking the secrets of Essentialism, tailor-made for busy biotech scientists like you. We discuss the importance of focusing o…
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41: Revealing the Disciplined Pursuit of Less in Bioprocessing - Part 1
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Hey, fellow scientists! Do you find yourself buried under an avalanche of tasks, unsure which one truly matters? If you're tired of the chaos and want to reclaim control of your time and energy, stick around. Today, we're unlocking the secrets of Essentialism, tailor-made for busy biotech scientists like you. We discuss the importance of focusing o…
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40: Balancing Perfusion Process Development and Sustainability w/ Jochen Sieck - Part 2
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Explore the intricate world of perfusion and its sustainability challenges in the part 2 of this episode. Dive into the operational side of managing vast quantities of media production and storage, and discover smart strategies to address these challenges. Jochen Sieck, Director of Cell Culture Media and Process Development at Merck Life Science, d…
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39: Balancing Perfusion Process Development and Sustainability w/ Jochen Sieck - Part 1
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Explore perfusion processes and sustainability with our guest, Jochen Sieck, Director of Cell Culture Media and Process Development at Merck Life Science. Learn about the evolution of perfusion methodologies, its historical roots in addressing product stability, and its recent return to continuous and integrated manufacturing. Jochen discusses the …
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38: How to Master Downstream: A Deep Dive Into Bioprocessing Purification w/ Wei Zhang - Part 2
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In part 2 of this insightful episode, we embark on a journey into the intricate world of biotech purification processes. Our guest, Wei Zhang, DSP Group Head at A*STAR Bioprocessing Technology Institute, delves into three key modalities, shedding light on the challenges and advancements in virus, RNA, and traditional vaccine purification. You will …
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37: How to Master Downstream: A Deep Dive Into Bioprocessing Purification w/ Wei Zhang - Part 1
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In this episode, Wei Zhang, DSP Group Head at A*STAR Bioprocessing Technology Institute, delves into the complexities of purification. Wei’s team pioneers bioprocessing processes for diverse biotherapeutics. You will gain valuable insights into the intricate challenges and innovative solutions in bioprocessing purification. You will learn: Master s…
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36: Smart Biotech Development Strategies for Adherent Cell Culture w/ Joel Eichmann - Part 2
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Welcome back to the second part of our insightful interview with Joel Eichmann, Managing Director of Green Elephant Biotech. In this episode, we delve deeper into the technical aspects of adherent cell expansion systems, explore sustainable biotech practices, and discuss key considerations for cost-efficient and environmentally friendly bioprocessi…
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35: Smart Biotech Development Strategies for Adherent Cell Culture w/ Joel Eichmann - Part 1
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Get ready for a deep dive into the world of bioprocess development as Joel Eichmann, Managing Director of Green Elephant Biotech, shares his expertise on smart strategies for adherent cell culture . Join us as we unravel the intricacies of adherent cell culture and discover the innovative strategies shaping the future of bioprocess development. You…
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34: The 7 Habits of Highly Successful Innovators - Part 2
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Uncover the secrets of successful innovators, including Steve Jobs, Elon Musk, and Thomas Edison, in this enlightening episode of our podcast. We dive deep into the habits that set these trailblazers apart and fuel their innovative spirit. Key learnings include: The power of curiosity and how it leads to groundbreaking ideas and improvements. The i…
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33: The 7 Habits of Highly Successful Innovators - Part 1
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Uncover the secrets of successful innovators, including Steve Jobs, Elon Musk, and Thomas Edison, in this enlightening episode of our podcast. We dive deep into the habits that set these trailblazers apart and fuel their innovative spirit. Key learnings include: The power of curiosity and how it leads to groundbreaking ideas and improvements. The i…
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32: The Future of Glycoengineering: Trends Unveiled w/ Thomas Rexer - Part 2
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Discover the hurdles and breakthroughs in glycoengineering, including the high costs of activated sugars. Thomas Rexer, CTO of eversyn, a spin-off of the Max Planck Institute Magdeburg, unveils eversyn's multi-step biocatalysis process, designed to significantly drive down costs and make in vitro glycoengineering more accessible on a large scale. K…
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31: The Future of Glycoengineering: Trends Unveiled w/ Thomas Rexer - Part 1
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Get ready for a crash course in glycoengineering as Thomas Rexer, CTO of eversyn, a spin-off of the Max Planck Institute Magdeburg, breaks down the significance of modifying glycans in biopharmaceuticals. Explore the science behind glycoengineering and its potential to enhance the properties of therapeutic proteins. Key Insights: Unlock new frontie…
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30: From Monoclonals to Gene Therapy: Tips for Process Development w/ Neil Templeton - Part 2
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In our insightful second part of the conversation, we broaden our perspective to delve into the various modalities within the biotech industry, highlighting the unique and shared aspects of process development and scale-up. Neil Templeton, the Director of Upstream Process Development at Solid Biosciences, passionately articulates his commitment tow…
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29: From Monoclonals to Gene Therapy: Tips for Process Development w/ Neil Templeton - Part 1
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In this enlightening episode, we're joined by Neil Templeton, Director in Upstream Process Development at Solid Biosciences, who pulls back the curtain on the intricate world of bioprocess development and manufacturing. Neil delves into the shifting paradigms of the industry, sharing his expert insights on overcoming the unique challenges that surf…
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28: How to Simplify Project Management in Bioprocess Development - Part 2
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Tackling bioprocess development and scale-up can be complex. While the science might be challenging, project management within biotech doesn't have to be. In this engaging episode, we'll guide you on how to streamline your CMC development, demystifying the complexities of project planning and execution. Here's what you'll gain: Discover the secret …
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27: How to Simplify Project Management in Bioprocess Development - Part 1
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Bioprocess development and scale-up are complex. Science may give you headaches, but biotech project management should not. In this riveting episode, you'll learn how to simplify your CMC development, guiding you through the maze of project planning and execution. Key Takeaways: Uncover how to "Plan for Success," ensuring your projects are well-str…
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26: 9 Critical Steps for a Seamless Transition to Large-Scale Production - Part 2
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In this riveting episode of the Smart Biotech Scientist podcast, we navigate the intricate labyrinth of biotech scale-ups. We distill the process down to 9 essential steps for a smooth transition from laboratory to large-scale production. Key Insights: Acquire Comprehensive Process Understanding: Bolster your decision-making and problem-solving ski…
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25: 9 Critical Steps for a Seamless Transition to Large-Scale Production - Part 1
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In this enlightening episode of the Smart Biotech Scientist podcast, we delve into the complex world of biotech scale-ups. We break down the 9 crucial steps to ensure a seamless transition from lab to large-scale production. Top 3 Takeaways: Gain Comprehensive Process Understanding: Enhance your decision-making and problem-solving abilities by thor…
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24: Strategies for Success: Master CMC Development with Gene Lee - Part 2
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If you've ever wondered how to seamlessly transition from R&D to process development, this is your golden ticket. Uncover practical strategies and expert advice that can be your compass through the intricate landscape of mastering CMC development. Uncover the challenges and tactics to seamlessly navigate this critical phase. Conduct Early Developab…
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23: Strategies for Success: Master CMC Development with Gene Lee - Part 1
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Embark on a journey into the intricate world of CMC development with our latest episode, unraveling the challenges that often baffle biotech scientists. The complexity of CMC development is a formidable hurdle, and in this insightful discussion, we delve into strategies to master this critical process. Key Takeaways: Start Early: Learn how starting…
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22: Unleashing Effective QbD Strategies to Master Cell Therapy with Shin Kawamata - Part 2
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Are you looking for advanced strategies to enhance the quality and efficiency of cell therapy manufacturing processes? In this episode with Shin Kawamata, CEO of Cyto-Facto Inc., we dive into the transformative power of digitization in cell therapy manufacturing and explore strategies to enhance efficiency and reduce costs. Actionable Takeaways: In…
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21: Unleashing Effective QbD Strategies to Master Cell Therapy with Shin Kawamata - Part 1
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Are the escalating costs and intricate technical hurdles of cell therapy development causing you stress? Tune into this insightful podcast episode featuring Shin Kawamata, CEO of Cyto-Facto Inc. in Kobe, Japan, who shares his expertise and innovative solutions to these pressing issues in the cell therapy industry. Discover how to streamline your ma…
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20: How to Take Your Molecule From the Lab to Clinical Trials w/ Bernardo Estupiñán Gaisbauer - Part 2
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Welcome to Part 2 of our conversation with Bernardo Estupiñán Gaisbauer, Principal at Drug Biologics Consulting. In this insightful episode, we dive into the complex world of taking a molecule from the lab to clinical trials. Our guest shares invaluable insights into outsourcing strategies for biotech companies. Key Learnings: Strategic Outsourcing…
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19: How to Take Your Molecule From the Lab to Clinical Trials w/ Bernardo Estupiñán Gaisbauer - Part 1
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Are you ready to unlock the secrets of taking your molecule from the lab to clinical trials? Join us in an exclusive interview with Bernardo Estupiñán Gaisbauer, a seasoned expert and principal at Drug Biologics Consulting, as he reveals the crucial steps and strategies necessary for a successful journey in CMC development. Biotech scientists often…
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18: How Extracting Gold From Your Data Accelerates Process Development w/ Ioscani Jiménez del Val - Part 2
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In part 2 of this interview with Ioscani, Assistant Professor at the School of Chemical & Bioprocess Engineering, University College Dublin, we delve into the art and science of accelerating process development through the strategic extraction of valuable insights from data. Our guest, a seasoned expert in computational modeling, unfolds the intric…
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17: How Extracting Gold From Your Data Accelerates Process Development w/ Ioscani Jiménez del Val - Part 1
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Join us as we unravel the complexities of computational methods in bioprocessing, featuring cutting-edge research on glycosylation and process development. Ioscani Jiménez del Val, Assistant Professor at the School of Chemical & Bioprocess Engineering, University College Dublin, explores the intricacies of creating computational models, closing the…
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16: Bacon Without Pigs? Innovations in Cultivated Meat Manufacturing with Beat Thalmann - Part 2
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In part 2, we explore the details of cost reduction in cultivated meat manufacturing, with a focus on two important factors: media and simplified bioreactors. Beat Thalmann, a passionate innovator and serial entrepreneur specializing in the development of animal-free cell culture systems, highlights the strategic importance of selecting the right c…
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15: Bacon Without Pigs? Innovations in Cultivated Meat Manufacturing with Beat Thalmann - Part 1
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Is bacon without pigs the future? In this episode, join us as Beat Thalmann, a passionate innovator and serial entrepreneur specializing in the development of animal-free cell culture systems, unveils the exciting possibilities. Discover how he overcomes the challenges of production and envisions a future where cultivated steak competes on price. B…
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14: Digital Transformation in Biomanufacturing: A Rapidly Moving Tech Frontier w/ Abhijeet Satwekar - Part 2
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Are you struggling to unlock the full potential of Process Analytical Technology (PAT) in biomanufacturing? Look no further! Join us for a game-changing conversation with Abhijeet Satwekar, an Innovation Manager at Merck Guidonia-Rome, Italy. Discover how PAT can revolutionize your decision-making, accelerate development timelines, and propel your …
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13: Digital Transformation in Biomanufacturing: A Rapidly Moving Tech Frontier w/ Abhijeet Satwekar - Part 1
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Wondering how you can leverage the immense potential of the rapidly evolving world of digital transformation in biomanufacturing? Join us as we explore the frontiers of technology and innovation with Abhijeet Satwekar, Innovation Manager at Merck Healthcare. Discover how cutting-edge digital technologies are revolutionizing bioprocesses, optimizing…
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12: From Lab to Patient: Steve Oh’s Guide to Mastering Cell Therapy Process Development - Part 2
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Welcome back to the second part of our exclusive interview with Steve Oh, former Institute Professor at the Bioprocessing Technology Institute (BTI) at the Agency for Science and Technology (A*STAR) and now Scientific Advisor to several international companies. In this episode, Steve dives deep into the challenges of manufacturing different cell ty…
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11: From Lab to Patient: Steve Oh’s Guide to Mastering Cell Therapy Process Development - Part 1
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Dive into the world of cell therapy process development with Steve Oh, former Institute Professor at the Bioprocessing Technology Institute (BTI) at the Agency for Science and Technology (A*STAR) and now Scientific Advisor to several international companies, as he shares thought-provoking perspectives and predictions on technologies that will impac…
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10: Revolutionizing Cell-Line Development: Unleashing the Power of Nanopens and Microenvironments w/ Tanner Nevill - Part 2
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Unlock the secrets of cell-line development with Tanner Nevill, the SVP of Applications at Bruker Cellular Analysis and one of the primary inventors and developers of the Beacon Optofluidic Platform. In this interview, Tanner delves into the transformative power of nanopens and microenvironments in cell-line development. Key Takeaways: Nanopens Red…
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09: Revolutionizing Cell-Line Development: Unleashing the Power of Nanopens and Microenvironments w/ Tanner Nevill - Part 1
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In this episode, Tanner Nevill, the SVP of Applications at Bruker Cellular Analysis and one of the primary inventors and developers of the Beacon Optofluidic Platform, shares insights into revolutionizing cell-line development through nanopens and microenvironments. Key Takeaways: Challenging the Status Quo: Tanner challenges conventional thinking,…
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08: Unveiling the Power of Microcarriers: Scaling Up Adherent Cell Cultures in Bioprocessing w/ Payar Radfar - Part 2
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In the second part of our insightful interview with Payar Radfar, CEO of Smart MCs, we delve into the practical steps of developing adherence cell cultures for bioprocessing scalability. Payar emphasizes the critical need for patience and a methodical approach, recounting how many clients rush into large-scale cultures prematurely. The key takeaway…
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07: Unveiling the Power of Microcarriers: Scaling Up Adherent Cell Cultures in Bioprocessing w/ Payar Radfar - Part 1
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In this episode, we explore the world of adherent cell cultures with Payar Radfar, CEO of Smart MCs. Smart MCs specializes in customized biomaterials and microfluidic solutions. Payar shares his unique journey in the biotech industry, driven by his passion for improving people's health. Key Takeaways: 1. Revolutionizing Bioprocessing: Payar discuss…
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06: Hybrid Modeling: The Key to Smarter Bioprocessing w/ Michael Sokolov - Part 2
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In the second part of our conversation with Michael Sokolov, the co-founder and COO of DataHow, we dive into practical insights on leveraging hybrid modeling in bioprocessing. You will discover: 1. Starting Small, Dreaming Big: Even in smaller companies, you can start with a minimal number of reactors and still leverage hybrid modeling effectively.…
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05: Hybrid Modeling: The Key to Smarter Bioprocessing w/ Michael Sokolov - Part 1
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In this insightful conversation, we explore how to accelerate bioprocess development and enhance manufacturing using hybrid modeling. Our guest, Michael Sokolov, COO of DataHow (a spin-off company from ETH Zurich), shares valuable insights. Discover the three major takeaways that could transform the bioprocessing industry: 1. Unlocking the Power of…
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04: How to Master Biotech Scale-up Without Guesswork w/ Leonardo Sibilio - Part 2
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In today's episode, we continue our fascinating conversation with Leonardo Sibilio, CEO of Biotech Academy and CSO at BetaPro Consulting. We delve into the pivotal role of structured training in the dynamic biotech industry. In this episode, you'll discover: - Foundation of Success: Leonardo emphasizes the importance of a strong foundation in GMP a…
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01: Unlock the Power of Rational Media Design in Bioprocessing w/ Tom Fletcher - Part 1
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In this episode with Tom Fletcher, R&D Director, Process development, Fujifilm Irvine Scientific, we delve into the world of bioprocessing. Tom shares insights into the transformative power of rational media design. From the complexities of bioprocess development to the game-changing potential of AI, this interview is a treasure trove of knowledge …
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02: Unlock the Power of Rational Media Design in Bioprocessing w/ Tom Fletcher - Part 2
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Welcome to a fascinating Smart Biotech Scientist episode! In this conversation, we dive deep into the nuts and bolts of rational media development with our guest, Tom Fletcher, R&D Director, Process development, Fujifilm Irvine Scientific. Together, we explore the immense potential of Rational Media Design and how it's transforming the industry. He…
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03: How to Master Biotech Scale-up Without Guesswork w/ Leonardo Sibilio - Part 1
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In this captivating episode, we delve into the world of biotech scale-up with the seasoned expert, Leonardo Sibilio, CSO at BetaPro Consulting and CEO of the Biotech Academy in Rome. Discover how mastering the art of biotech scale-up can transform your journey from doubt to dominance. Key Takeaways: 1. Early Planning is Paramount: Leonardo emphasiz…
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Biotech Simplified: Your Path to Bioprocess Mastery Unveiled (Trailer)
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Are you a busy biotech scientist, trying to navigate the complex world of bioprocessing while fueling your passion for science? Join us on the Smart Biotech Scientist Podcast, where we're about to unravel the secrets to bioprocess mastery. Hosted by a seasoned biotech leader and entrepreneur with over 15 years in the industry, this podcast is your …
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Cashflow - incentivising early payments to strengthen supply chains
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In this episode, our Network Development Manager, Matt Blakeley, talks to Ant Persse, chief executive of Saltare, about how they're working with SMEs to incentivise early payments along their supply chains to reduce late payments and keep cash flowing between businesses. It is estimated that 82% of businesses fail not because of lack of profit, but…
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The Power of Culture with Karina Rook
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We talk in this episode with Karin Rook from Ventures Green about the value of having a strong and positive organisational structure. When exploring productivity we often over look the human element and we hope that in this podcast we can explore the value of this and the benefits it can bring to your business. In these challenging times as an empl…
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