Discovery Matters podcast

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Love Is Blind UK: The Official Podcast

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Katisha and Javen talk triangles and photobooths with Sam Prince and Liv Bentley 37:22

7 hari yang lalu37:22

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37:22

Sarel is back to delve into all the drama from this week's drop of Love is Blind UK. Javen opens up about his time in the pods and responds to claims on social media that he was playing a game…. Meanwhile, Katisha reveals what she thought of Javen after the mixer. Expect emotional confessions and awkward confrontations with reality royalty Liv Bentley and Sam Prince. Subscribe now and buckle up for the ultimate Love Is Blind UK experience! Listen to more from Netflix Podcasts.…

Discovery Matters

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A collection of stories and insights on matters of discovery that advance life sciences. Brought to you by the curious people at Cytiva.

107 episode

#Science #Biology #Discovery Matters

Discovery Matters

21 subscribers

updated sekitar setahun yang lalu

Beranda serial•Feed

A collection of stories and insights on matters of discovery that advance life sciences. Brought to you by the curious people at Cytiva.

107 episode

#Science #Biology #Discovery Matters

Semua episode

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106. Zoonotic diseases 23:08

9 weeks yang lalu23:08

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In this episode, we explore zoonotic diseases and their growing impact on global health. Professor Clare Bryant, sheds light on strategies to vaccinate animals to prevent pathogen transmission into humans. We also delve into the historical context of the disease, the role of vaccines, and the importance of coordinated public health. Whether you're a public health professional or simply curious about emerging infectious diseases, this episode offers a comprehensive look at the science, challenges, and solutions surrounding zoonotic diseases.…

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105. What is pain? 32:11

13 weeks yang lalu32:11

32:11

Pain. It comes in many forms: physical and emotional. But do we really understand it? This episode will attempt to answer fundamental questions about what pain is, how it is experienced, and why it is such a critical aspect of human existence. We speak with Prof Jeff Mogil to discuss sex differences in pain. His work has been influential in promoting the inclusion of both sexes in pain research, ensuring that treatments and pain management strategies are more effective for everyone. We are also joined by Steve Ruston, CEO of Persica, to discuss non-opioid intradiscal injection to treat chronic low back pain caused by bacterial infection. Show notes Nanoparticle gel could help save degraded coral reefs Plants struggled for millions of years after the world's worst climate catastrophe…

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104. Vaccines: Inverse v traditional 36:56

17 weeks yang lalu36:56

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Today, we're diving into a topic that's not just reshaping the world of vaccines—it's flipping it on its head. We're exploring the cutting-edge realm of inverse vaccines with Prof Lawrence Steinman and how they're revolutionizing the approach to treating autoimmune diseases. Plus, we'll chat with CancerVax, who are using the immune system in a radically different way, aiming to make it attack cancer cells just like it would fight off a virus like measles.…

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103. How space impacts the body 43:27

18 weeks yang lalu43:27

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Ever wonder what happens to your body when you leave Earth behind? In this gravity-defying episode, we launch into the weird, wild world of human biology in space. From the first C. elegans in space to the NASA Twins Study to future deep space missions, we have a lot to discuss. Strap in as we float through the science of space adaptation. Spoiler: space may teach us about our Earth-bound health. Show notes • Deane, Colleen S, et al. (2023) Comparative analysis of muscle atrophy during spaceflight, nutritional deficiency and disuse in the nematode caenorhabditis elegans. International Journal of Molecular Sciences, 24 (16), [12640]. • Francine E. Garrett-Bakelman et al. (2019) The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight. Science, 364 (8650). • Bokhari RS, et al. (2022) Looking on the horizon; potential and unique approaches to developing radiation countermeasures for deep space travel. Life Sci Space Res (Amst), 35 (105-112). • Glavin, D.P., et al. (2025) Abundant ammonia and nitrogen-rich soluble organic matter in samples from asteroid (101955) Bennu. Nat Astron 9 (199–210). • Eyting, M., et al. (2025) A natural experiment on the effect of herpes zoster vaccination on dementia. Nature.…

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102. Fighting diabetes differently 27:13

22 weeks yang lalu27:13

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What's new with insulin? Jeppe Sturis and his team at Novo Nordisk have a new hypothesis. They challenge the long-held belief that insulin resistance comes from faulty tissues, suggesting instead that the real culprit is insulin breaking down before it even reaches its target. This fresh perspective could reshape how we fight diabetes.We will also hear from Diamyd Medical’s advancing research on antigen-specific immunotherapy which could change the game by protecting insulin-producing cells and slowing the progression of Type 1 diabetes.…

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101. Unleashing AI: Adventures in discovery 30:31

23 weeks yang lalu30:31

30:31

Join us for a fascinating deep dive into how generative AI is revolutionizing healthcare and life sciences! We unveil groundbreaking advancements in drug discovery, clinical trials, and diagnostics—showcasing AI’s growing role in shaping the future of medicine. With expert insights from Shweta Maniar (Google Cloud) and Martin Stumpe (Danaher), we’ll explore how AI accelerates innovation through data-driven breakthroughs while keeping humans at the heart of the process for trust and accountability. Show notes Researchers identify a brain circuit for creativity…

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95. Modality convergence in advanced therapies 16:45

29 weeks yang lalu16:45

16:45

Join us in this lite bite episode as Dr. Aravind Asokan, Duke University, explores cutting-edge technologies revolutionizing advanced therapies, including CRISPR, mRNA, viral vectors, and cell therapies. He shares key lessons from past challenges, discusses scalability, product quality, and how integrating various therapeutic approaches is shaping the future of disease treatment. This episode covers exciting advancements in AAV with CRISPR, CAR T cell therapy, circular RNA, and virus-like particles (VLPs). Show notes Asokan A, et al. ‘An evolved AAV variant enables efficient genetic engineering of murine T cells’. Cell. 2023 Jan 19;186(2):446-460. https://doi.org/10.1016/j.cell.2022.12.022…

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100. Best of 2024 16:42

35 weeks yang lalu16:42

16:42

In this special celebratory milestone episode, we mark our 100th episode with a vibrant recap of year. Get ready to dive into fascinating conversations, from the squirrely intelligence of cephalopods and their chameleon-like abilities to cutting-edge antibody drug conjugates (ADCs) revolutionizing cancer treatment, to an enlightening chat with Nobel Laureate Dr. Michael Houghton on the crucial path to combating hepatitis C.…

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99. Re-run: One hundred years of insulin 18:27

36 weeks yang lalu18:27

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Insulin's discovery in 1921 transformed diabetes from a certain death sentence to a manageable chronic condition, revolutionizing modern medicine. In this episode of Discovery Matters , we look back to our episode on a fascinating journey through 100 years of insulin advancements and its profound impact on diabetes treatment. Listen in to appreciate 100 years of ground-breaking science and anticipate what the future holds for diabetes treatment.…

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98. Detective work in Parkinson's Disease 25:36

36 weeks yang lalu25:36

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In this episode of Discovery Matters we delve into groundbreaking advancements in Parkinson’s disease research. Dodi and Conor transport us to the frontier of medical innovation, exploring the latest discoveries and techniques that hold promise for early diagnosis and treatment of Parkinson’s disease. Show notes • Decet, Marianna et al. ‘ A candidate loss-of-function variant in SGIP1 causes synaptic dysfunction and recessive parkinsonism’ , Cell Reports Medicine, Volume 5, Issue 10. • Hällqvist, J., Bartl, M., Dakna, M. et al. ‘ Plasma proteomics identify biomarkers predicting Parkinson’s disease up to 7 years before symptom onset’ . Nat Commun 15, 4759 (2024). • Roald Dahl's Marvellous Children's Charity Keywords : non-invasive procedure, early diagnosis, synaptic homeostasis, Parkinsonism, biomarkers, machine learning, REM sleep disorder, inflammatory pathways, dopaminergic cells, predictive diagnostics, early intervention.…

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97. Re-run: The discovery of Protein A 15:03

39 weeks yang lalu15:03

15:03

In this re-released episode we revisit protein A. We will dive back into the history and science of protein A. But what exactly sets protein A apart? Is it really the top choice for antibody purification because of its alphabetical ranking, or is there more to the story? And what about its counterparts, proteins G and L?…

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96. Re-run: Tea, jam and protein separation 17:52

40 weeks yang lalu17:52

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As we approach our one hundredth episode, travel back with us to the origins of the podcast in our premiere episode, "Team and Jam and Protein Separation." In this debut, we explored the vital process of protein separation—an essential technique in biochemistry and pharmaceuticals that continues to impact human health in significant ways.…

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94. Discovery Maker: Dr Michael Houghton 18:07

46 weeks yang lalu18:07

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Dive into the fascinating world of virology as we welcome Nobel Prize-winning virologist Dr. Michael Houghton on this episode of Discovery Matters. We explore Dr. Houghton's groundbreaking work in identifying the hepatitis C virus (HCV) and his enduring quest to combat this global health threat. From the monumental discovery of HCV in 1982 to the revolutionary diagnostic tests that nearly eradicated transfusion-related hepatitis C by the mid-1990s, Dr. Houghton provides an engaging and insightful journey through decades of scientific innovation. Show notes Richard D Roberts, Patrick C Kyllonen, ‘Morningness–eveningness and intelligence: early to bed, early to rise will likely make you anything but wise!’ Personality and Individual Differences, Volume 27, Issue 6, 1999. https://doi.org/10.1016/S0191-8869(99)00054-9 . Taquet, MaximeLone, Nazir et al. ‘Cognitive and psychiatric symptom trajectories 2–3 years after hospital admission for COVID-19: a longitudinal, prospective cohort study in the UK.’ The Lancet Psychiatry, Volume 11, Issue 9. https://doi.org/10.1016/S2215-0366(24)00214-1…

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93. How sustainable is biopharma? 27:06

48 weeks yang lalu27:06

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Eco-design, collaboration, circular economy. These are the bywords of sustainability in biopharma. Join Ryan Walker, Senior Director of Sustainability at Cytiva, and Aude Arkham, Global Head of Eco Design and Circular Economy at Sanofi, as they explore how eco-design and circular economy initiatives are shaping the future of healthcare. We delve into challenges, achievements, and the transformational potential of sustainability efforts within biopharma. From Sanofi’s life cycle assessments to industry-wide data difficulties, this episode navigates the complex landscape of creating greener solutions without compromising innovation and compliance.…

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92. Big data, AI, and the problem of averages 26:20

51 weeks yang lalu26:20

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In this episode of "Discovery Matters," we dive into the powerful intersection of big data and artificial intelligence. Joined by Matej Macak, a partner from McKinsey, we unravel how AI and machine learning are revolutionizing our approach to finding new, effective medications. With Tom Yankeelov, Professor of Biomedical Engineering, Diagnostic Medicine, Oncology at the University of Texas for Austin, we'll explore the "problem of averages" and much more.…

Discovery Matters

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91. The body as a bioreactor 33:30

1 year yang lalu33:30

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What does 'the body as a bioreactor' mean? In this discussion how scientists use the body's machinery to produce therapeutic proteins. Scott Ripley, General Manager of Nucleic Acids at Cytiva, explains that traditional bioprocessing uses external bioreactors, while the new approach leverages the body's natural processes. This method offers benefits like longer protein half-life and the ability to express multiple proteins simultaneously. Justin Eyquem, assistant professor at University of California San Francisco, discusses the potential of in vivo CAR T cell therapy, which could simplify manufacturing and reduce costs. Both approaches face challenges in quality assurance and regulatory approval but hold promise for personalized and more effective treatments.…

Discovery Matters

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90. Advanced therapies (Part 2) 20:42

1 year yang lalu20:42

20:42

We're diving into advanced therapies with industry leaders. Emmanuel Abate, President of Genomic Medicine at Cytiva discussed the strategies to accelerate clinical work and reduce costs. Nathaniel Wang, CEO and Co-Founder of Replicate Bioscience highlighted their ground breaking self-replicating RNA technology, showcasing impressive clinical results for a rabies vaccine. Both experts emphasized the momentum in biotech, the potential of AI in advancing science, and the importance of making innovative therapies accessible globally. Stay tuned for these insights. Show notes Beneath Everest, a lone caretaker struggles to keep one of the world’s highest laboratories alive Integrating human endogenous retroviruses into transcriptome-wide association studies highlights novel risk factors for major psychiatric conditions Keywords : vaccines, advanced therapies, mRNA, manufacturing, technology, patients, innovation, new modalities.…

Discovery Matters

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89. Advanced therapies (Part 1) 34:33

1 year yang lalu34:33

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From gene and cell therapies, to the use of CRISPR and other precision engineering technologies, this episode dives into the opportunities and challenges of the emerging field of advanced therapies. On Discovery Matters this week, Dodi and Conor are joined by Daria Donati, Chief Scientific Officer of Genomic Medicine at Cytiva, as well as Jen Moody, Vice President of External Innovation of Genomic Medicines at Danaher, to discuss the science, progress, and potential of advanced therapeutics. Demaris Mills, Group Executive of Genomic Medicines at IDT, and experts Fyodor Urnov, Professor of Molecular and Cell Biology at the University of California, Berkeley, and the Director of Technology & Translation at the Innovative Genomics Institute, cover the technologies used in gene and cell therapies as well as CRISPR to deliver powerful and precise treatments aiming for a healthier future.…

Discovery Matters

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88. Replicants and reality 21:15

1 year yang lalu21:15

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Can you tell the difference between a human and AI? Of course you can…right? We challenge Conor and Dodi to tell the difference between Conor and Conor BOT all while uncovering how AI is transforming the life sciences. Uncover how AI is transforming the life sciences. Together with an AI-bot the pair explore the potential applications of AI in drug discovery, personalizing medical treatments, protein folding, and more. They also consider the ethical considerations required when developing AI models, as well as the need for emotional intelligence in AI systems. Keywords : AI, ethical dilemma, bias, misinformation, datasets, diagnostics, drug discovery, healthcare.…

Discovery Matters

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87. Cephalopods: From camouflage to communication 29:14

1 year yang lalu29:14

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Let's explore the remarkable colour-changing abilities of cephalopods. Joined by Dan Wilson from the Kostas Research Institute at Northeastern University, the team dive into the fascinating research behind the development of paints that respond to environmental stimuli, such as sunlight. They also discuss titanium dioxide and how it acts as a facilitator of the colour-changing process. Professor Alon Gorodetsky, Associate Professor of Chemical and Biomolecular Engineering at the University of California, Irvine, talks about his research on developing energy-responsive dyes to mimic the features of octopi. Discover the potential applications of these dyes from diagnostics to resource-constrained initiatives, and more. Listen in and discover this remarkable evolutionary adaptation and the incredible ingenuity of cephalopods.…

Discovery Matters

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86. Synthetic biology 29:39

1 year yang lalu29:39

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In this episode of Discovery Matters, hosts Dodi and Conor explore how synthetic biology can lead to transformative breakthroughs when it comes to dealing with global health problems. Through their conversation with Justin Vigar, a PhD student in Dr. Keith Pardee's lab at the University of Toronto in Canada, we learn how his team's paper-based diagnostic tool has the potential to provide faster, more cost-efficient, and accessible diagnostics for underserved locations. This is complemented by Amir Pandi and Tobi Erb's discussion of using AI and synthetic biology to develop new antimicrobial peptides. Show notes • U of T PhD student uses synthetic biology to create low-cost diagnostic tools . • Pandi, A., Adam, D., Zare, A. et al. Cell-free biosynthesis combined with deep learning accelerates de novo-development of antimicrobial peptides. Nat Commun 14, 7197 (2023). https://doi.org/10.1038/s41467-023-42434-9 • Khalek IS, et al. Synthetic development of a broadly neutralizing antibody against snake venom long-chain α-neurotoxins. Sci Transl Med. 2024 Feb 21;16(735). https://doi.org/10.1126/scitranslmed.adk1867 • Josh A Goldstein, Jason Chao, Shelby Grossman, Alex Stamos, Michael Tomz, How persuasive is AI-generated propaganda?, PNAS Nexus, Volume 3, Issue 2, February 2024. https://doi.org/10.1093/pnasnexus/pgae034…

Discovery Matters

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85. Drugging the undruggable 26:23

1 year yang lalu26:23

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Tune in to Discovery Matters to see how we can drug the undruggable. Dodi and Conor talk to Mark Bray, a second year PhD student in the Bowman Lab at the University of Pennsylvania, about the concept of “drugging the undruggable” for drug discovery and development. They discuss advances in medical research which has enabled us to drug molecular targets that were previously inaccessible, and the strategies that are used to devise and find effective drugs. Vicky Richon, CEO at Entact Bio, elucidates the importance of a revolutionary “induced proximity” modality for unprecedented drug treatments. Listen to this episode to understand modern approaches to treating diseases and uncovering cures.…

Discovery Matters

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84. Unraveling biotech's AI transformation 30:25

2 years yang lalu30:25

30:25

Explore the potential of artificial intelligence (AI) and machine learning to revolutionize biomedical research and make personalized healthcare a reality. Tune in to Discovery Matters to see how AI and machine learning will be the future of biomedical research. Featuring interviews with Professor Kourosh Saeb-Parsy and Dr Namshik Han — leaders in the AI and biotech space — this episode delves into the significance of advanced technology for unlocking discoveries in transplantation, understanding the causes of diseases, precision medicine, and more. Show notes: This AI learnt language by seeing the world through a baby’s eyes Computational phylogenetics reveal histories of sign languages…

Discovery Matters

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83. Antibody drug conjugates 29:05

2 years yang lalu29:05

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Let’s explore the world of antibody drug conjugates (ADCs) and their potential for improving human health. Our two guests—Principal Investigator Sasha Ebrahimi from GSK and oncologist Dr. Paolo Tarantino—discuss the development and advantages of ADCs, and how they can be used to personalize treatments for cancer and other illnesses. Sasha explains how ADCs combine the targeting capabilities of antibodies with the cytotoxic effects of drugs, while Dr. Tarantino delves into his research with breast cancer and immunotherapies. Learn more about the possibilities of ADCs in this insightful episode of Discovery Matters. Keywords : antibody drug conjugates, adc, chemotherapy, antibodies, cancer, oncology, patient, breast cancer.…

Discovery Matters

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82. Best of 2023 17:16

2 years yang lalu17:16

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Discovery Matters is back with our best episodes and insights from the past year. Dodi and Conor re-explore some cutting-edge ideas and technologies pushing the frontiers of science and medicine forward. We look back on some of our favorite episodes including therapies such as psychedelic drugs, the sentience of brain cells, and the potential of marine microbes to fight cancer. They explore the potential of DNA to create medicine, the use of organoids in drug testing, and the use of cryopreservation for cell therapies. Join us as we uncover newer and better ways of improving health through science. Find out why Discovery Matters to you and the world by tuning into this episode.…

Discovery Matters

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80. Different strokes from different folks 24:44

2 years yang lalu24:44

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Join Conor and Dodi in the latest episode of Discovery Matters , as they explore the wonders of ground-breaking scientific discoveries from multidisciplinary collaboration. MIT's Professor Pete Dedon expresses how multidisciplinary approaches and unique combinations of experiences can help to produce unexpected results. Professor James Evans of the University of Chicago then brings in the concept of surprise and hypergraphs to uncover the connections between different fields of knowledge. With insights from their guests, the latest episode of Discovery Matters dives deep into the mechanics behind groundbreaking discoveries. Jump in and listen to discover new ways to think about innovations and uncover the next amazing breakthrough! Keywords : multidisciplinary, ideas, papers, surprise, science, combinations, teams, antibiotics, compounds, infectious diseases, malaria, space, serendipity.…

Discovery Matters

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79. Patient-derived organoids (part 2): Organic electronic materials 35:31

2 years yang lalu35:31

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Let’s explore the world of organoids and their potential to revolutionize disease treatment. Joined by Matthias Zilbauer and Roisin Owens, we look at the interplay of the gut-brain axis with organic electronic materials. Dive into the advances in organoid and microbial models used to develop treatments for illnesses such as Irritable Bowel Syndrome (IBS), Crohn’s Disease, and Ulcerative Colitis. Join Dodi and Conor to discover how bioengineering could change our understanding of health and disease - and our lives. Transcript Show notes Shi, F., Evans, J. Surprising combinations of research contents and contexts are related to impact and emerge with scientific outsiders from distant disciplines. Nat Commun 14, 1641 (2023). https://doi.org/10.1038/s41467-023-36741-4. Moon landing: India’s home-grown tech cut the costs (nature.com) Keywords : microbiome, patient, model, cells, tissue, disease, gut, biological systems, microbes, biology, pediatric gastroenterology, science, organoids…

Discovery Matters

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78. Lipid nanoparticles: a special delivery service 26:07

2 years yang lalu26:07

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In this episode of Discovery Matters , we discuss the exciting potential of lipid nanoparticles (LNPs) to deliver genetic material and therapeutics to target cells and tissues. We are joined by Lloyd Jeffs, Senior Director of Biopharma Services at Precision NanoSystems, and Prof Dan Peer, Director of the Laboratory of Precision Nanomedicine at Tel Aviv University. Dan shares how his team has developed siRNA LNPs to deliver treatment more efficiently for ovarian cancer patients. From Dan's unique perspective, learn why this technology is cutting-edge, and why it may help defeat one of mankind’s biggest enemies— cancer. Transcript Show notes Therapeutic gene silencing of CKAP5 leads to lethality in genetically unstable cancer cells | Science Advances Neuroscientists decoded a Pink Floyd song using people’s brain activity (sciencenews.org) Nutrients | Free Full-Text | Does Pizza Consumption Favor an Improved Disease Activity in Rheumatoid Arthritis? (mdpi.com) Keywords : ovarian cancer, nanoparticles, lipid nanoparticles, genomic medicine, tumour, nucleic acids, cells, chemotherapy, drug, mrna, patients, sirna, rna.…

Discovery Matters

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81. Access in developing nations 38:18

2 years yang lalu38:18

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Challenges of improving access to healthcare in developing countries - it's a conversation we need to have. With the help of Dr Jerome Kim, Director General of the International Vaccine Institute, we discuss vaccination and immunization programs as a key aspect of public health and global development – especially in developing nations, where access to life-saving medicines is often limited or non-existent. Karen Heichman, Deputy Director of Diagnostics, Bill and Melinda Gates Foundation, takes us on a journey of the critical role of diagnostics in the fight against diseases. Tune in to hear how technology and innovation could help to bridge the gap in access to healthcare and potentially save lives in the process.…

Discovery Matters

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77. Combination therapies and serendipity 22:14

2 years yang lalu22:14

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Through a discussion of combination therapies, Dodi and Conor delve into the mysterious power of the human microbiome, and antimicrobial resistance. With evidence of the microbiome being a key factor in fighting diseases, this episode highlights the importance of understanding and treating the microbiome and its potential to improve lives. Tune in to find out more and explore the possibilities of the microbiome with Dr Saman Maleki, and the power of serendipity with Prof Pete Dedon! Transcript Show notes Routy, B., Lenehan, J.G., Miller, W.H. et al. Fecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial. Nat Med 29, 2121–2132 (2023). A novel combination therapy counters antibiotic-resistant Mycobacterium abscessus infections (MIT news) 'Blight' warns that a future pandemic could start with a fungus (sciencenews.org) Hildebrandt, T., Peyser, D. The gut microbiome in anorexia nervosa. Nat Microbiol 8, 760–761 (2023). Keywords : microbiome, patients, immunotherapy, immune system, cancer, study, people, combination therapy, tumor, immuno-oncology, fungus, fecal transplant, anorexia nervosa, oncology, higher bmi…

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