Bitcoin groundbreakers share personal stories of how Bitcoin is changing lives for the better. Host Mauricio Di Bartolomeo, co-founder and CSO of Ledn, speaks with leading Bitcoin voices, entrepreneurs, and human rights advocates to hear their unique journey and practical real-world examples of how Bitcoin has made a positive impact in their lives. Brought to you by Ledn, a leading financial services company built for Bitcoin & digital assets. Ledn offers a suite of lending, saving and tradi ...
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On the Bus with Troy Vollhoffer

1 The Hillbillies of the British Invasion With The Boxmasters 32:52
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After growing up watching The Who on the Ed Sullivan Show, the members of The Boxmasters never dreamed of having the chance to tour with one of the greatest bands in the world, but here they are. Country Thunder CEO Troy Vollhoffer welcomes Billy Bob Thornton and JD Andrew of The Boxmasters to On The Bus . The duo walks Troy through their happenstance meeting and how the British Invasion and “hillbilly music” are such major influences in their work. Billy Bob reveals why, despite all of the major successes he’s had in TV and film, his greatest passion will always be music. JD and Billy Bob explain how they went from appearing in The Trailer Park Boys to singing at Abbey Road, and how their music often reflects on missing the simple things in life, like putting a quarter in a payphone.…
Origins - Inside Venture Capital, Hosted by a GP and an LP
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Konten disediakan oleh OpenLP from Sapphire Partners. Semua konten podcast termasuk episode, grafik, dan deskripsi podcast diunggah dan disediakan langsung oleh OpenLP from Sapphire Partners atau mitra platform podcast mereka. Jika Anda yakin seseorang menggunakan karya berhak cipta Anda tanpa izin, Anda dapat mengikuti proses yang diuraikan di sini https://id.player.fm/legal.
Hosted by a General Partner (GP) and a Limited Partner (LP), Origins dives into the venture capital ecosystem to learn how the people behind the money make decisions: How LPs choose VC funds to invest in, what drives performance in venture, the dos and don'ts of fundraising, what founders/entrepreneurs/CEOs need to do to raise a Seed, Series A and beyond, what it takes to go from emerging manager to franchise VC, and the latest private market trends and dynamics shaping the investment ecosystem. Origins is co-hosted by GP Nick Chirls and LP Beezer Clarkson.
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115 episode
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Konten disediakan oleh OpenLP from Sapphire Partners. Semua konten podcast termasuk episode, grafik, dan deskripsi podcast diunggah dan disediakan langsung oleh OpenLP from Sapphire Partners atau mitra platform podcast mereka. Jika Anda yakin seseorang menggunakan karya berhak cipta Anda tanpa izin, Anda dapat mengikuti proses yang diuraikan di sini https://id.player.fm/legal.
Hosted by a General Partner (GP) and a Limited Partner (LP), Origins dives into the venture capital ecosystem to learn how the people behind the money make decisions: How LPs choose VC funds to invest in, what drives performance in venture, the dos and don'ts of fundraising, what founders/entrepreneurs/CEOs need to do to raise a Seed, Series A and beyond, what it takes to go from emerging manager to franchise VC, and the latest private market trends and dynamics shaping the investment ecosystem. Origins is co-hosted by GP Nick Chirls and LP Beezer Clarkson.
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115 episode
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Origins - Inside Venture Capital, Hosted by a GP and an LP

1 Staying Small Despite Billion-Dollar Backings with Micah Rosenbloom 44:57
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Micah Rosenbloom is a Managing Partner at Founder Collective, a firm dedicated to seed investing and, crucially, to keeping their fund sizes below $100 million. Micah talks with Beezer Clarkson, Partner at Sapphire Partners, and Nick Chirls, Partner at Asylum Ventures, to discuss Founder Collective’s philosophy of keeping their fund size small to avoid the “billions or bust” mentality, how most investors have a bad track record of spotting trends at seed, and how consumer goods are still worthwhile investments even against the backdrop of AI. They also debate a recent post from Nick to get to the fundamental question of whether investors taking big risks are courageous or lucky. Learn more about Sapphire Partners: sapphireventures.com/sapphire-partners Learn more about OpenLP: openlp.vc Learn more about Asylum Ventures: asylum.vc Learn more about Founder Collective: foundercollective.com For a monthly roundup of the latest venture insights, including the newest Origins episodes, subscribe to the OpenLP newsletter – delivered straight to your inbox: subscribe.openlp.vc CHAPTERS: 0:00 Welcome to Origins 2:16 What Can Small Do For You?8:57-A Whole Team of Ex Operators 14:52 How Micah’s View of the Market Has Changed18:48-Why the Market’s Tough Right Now 21:49 Early Stage VCs Are Usually Seven Years Too Late 30:14 Investing: Courage or Luck?42:59-Predictions for 2026…
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Origins - Inside Venture Capital, Hosted by a GP and an LP

1 Minisode: What Early Stage Venture Can Learn from Crypto Traders 10:11
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Origins host Beezer Clarkson, LP at Sapphire Partners and co-founder of OpenLP, and Nick Chirls, GP at Asylum Ventures, dive into their recent conversation with Kyle Samani, Founder and Managing Partner of Multicoin Capital. They discuss their learnings on crypto, including why Nick is more bullish on bitcoin than Kyle, and how LPs conceptualize investing in firms like Multicoin. They also break down why people who came up as Crypto traders and investors are uniquely positioned to excel in early stage venture. Learn more about Sapphire Partners: sapphireventures.com/sapphire-partners Learn more about OpenLP: openlp.vc Learn more about Asylum Ventures: asylum.vc Learn more about Multicoin: multicoin.capital For a monthly roundup of the latest venture insights, including the newest Origins episodes, subscribe to the OpenLP newsletter – delivered straight to your inbox: subscribe.openlp.vc CHAPTERS: 0:00 Welcome to Origins 1:02 Is Bitcoin an Unproductive Asset? 1:56 The Problem With Web3.0 3:49 Assessing Crypto Managers As an LP 6:21 The Hard Part Isn’t Buying Bitcoin, It’s Holding It 8:21 Trained In Crypto, Excelling In Traditional Markets…
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Origins - Inside Venture Capital, Hosted by a GP and an LP

1 Internet Capital Markets with Kyle Samani 43:54
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Kyle Samani is the Founder and Managing Partner of Multicoin Capital, a thesis-driven investment firm that invests in cryptocurrencies, tokens, and blockchain companies reshaping trillion-dollar markets. He joins Beezer Clarkson, Partner at Sapphire Partners, and Nick Chirls, Partner at Asylum Ventures, to discuss the philosophies that underpin Multicoin’s investment strategies. He also unpacks how blockchain technologies are already reshaping global finance away from legacy systems and towards embedded trading platforms that will sit within traditional messaging and media platforms. Learn more about Sapphire Partners: https://sapphireventures.com/sapphire-partners Learn more about OpenLP: https://openlp.vc Learn more about Asylum Ventures: https://asylum.vc Learn more about Multicoin: https://multicoin.capital Jerry Neumann’s post on markets v. innovation: https://reactionwheel.net/2025/07/a-look-at-growth For a monthly roundup of the latest venture insights, including the newest Origins episodes, subscribe to the OpenLP newsletter – delivered straight to your inbox: subscribe.openlp.vc CHAPTERS: 0:00 Welcome to Origins 2:43 The Origin Story of Multicoin 7:07 Financially Long & Intellectually Short Bitcoin 8:53 What Is an Internet Capital Market? 19:18 What Happens to Banks? 21:14 What Did You See In Solana? 30:22 The Rise of DATs 36:40 Did Web3.0 Live Up To Its Promise?…
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Origins - Inside Venture Capital, Hosted by a GP and an LP

1 Minisode: Can LPs Diversify in an AI-Obsessed World? 9:44
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Origins host Beezer Clarkson, LP at Sapphire Partners and co-founder of OpenLP, and Nick Chirls, GP at Asylum Ventures, unpack their recent conversation with Sarah Tavel, Partner at Benchmark. Together they discuss their takeaways from Sarah’s recent decision to take a step back at Benchmark to fully focus on AI, getting into the lessons they can learn from that approach and what that means for the future of artificial intelligence. They also discuss the current state of venture in light of this decade’s AI boom, and theorize where this will put the ecosystem in the future. This episode of Origins is supported by Sydecar. Visit https:// sydecar.io/origins-podcast to learn more. Learn more about Sapphire Partners: https://sapphireventures.com/sapphire-partners Learn more about OpenLP: https://openlp.vc Learn more about Asylum Ventures: https://asylum.vc Learn more about Benchmark: https://benchmark.com Read Sarah’s Substack Posts: https://sarahtavel.com For a monthly roundup of the latest venture insights, including the newest Origins episodes, subscribe to the OpenLP newsletter – delivered straight to your inbox: https://subscribe.openlp.vc Sydecar, Inc. (“Sydecar”) has acted as a financial sponsor within this Origins podcast. Sapphire Ventures, LLC (“Sapphire”) is not affiliated with or invested in Sydecar. CHAPTERS: 0:00 Welcome to Origins 0:48 How Do We Carve Out More Time For Thinking? 3:02 How Are LPs Handling AI Risk? 6:02 Can You Achieve AI Diversity as an LP?…
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Origins - Inside Venture Capital, Hosted by a GP and an LP

1 Becoming AI Native with Benchmark’s Sarah Tavel 42:27
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Eight years after becoming the first female partner at Benchmark, Sarah Tavel recently took on a new role as Venture Partner that allows her more time to fully immerse herself in AI, all while continuing to make new investments on behalf of Benchmark and serving her current portfolio. She sat down with Beezer Clarkson, Partner at Sapphire Partners, and Nick Chirls, Partner at Asylum Ventures, to unpack her learnings over the past few months, including what it means to be truly AI native, how the future of AI is social (not solo), and what that means for AI tools and the people who use them. She also discusses the importance of protecting your time as a VC and the advantages of devoting time each week to play. This episode of Origins is supported by Sydecar. Visit sydecar.io/origins-podcast to learn more. Learn more about Sapphire Partners: https://sapphireventures.com/sapphire-partners Learn more about OpenLP: https://openlp.vc Learn more about Asylum Ventures: https://asylum.vc Learn more about Benchmark: https://benchmark.com Read Sarah’s Substack Posts: https://sarahtavel.com For a monthly roundup of the latest venture insights, including the newest Origins episodes, subscribe to the OpenLP newsletter – delivered straight to your inbox: https://subscribe.openlp.vc Sydecar, Inc. (“Sydecar”) has acted as a financial sponsor within this Origins podcast. Sapphire Ventures, LLC (“Sapphire”) is not affiliated with or invested in Sydecar. CHAPTERS: 0:00 Welcome to Origins 1:46 Living & Breathing AI 8:58 AI As Both Solo & Social 16:13 What Does It Mean to be AI Native? 23:19 How Do Our Brains Need to Adapt to AI? 31:37 How AI Immersion Has Changed Sarah’s Investment Strategy 37:56 Looking For AI Frontier Companies & the Businesses Around Them…
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Origins - Inside Venture Capital, Hosted by a GP and an LP

Origins host Beezer Clarkson, LP at Sapphire Partners and co-founder of OpenLP, and Nick Chirls, GP at Asylum Ventures, dig into their recent conversation with Alex Edelson, LP at Slipstream. They discuss whether a spate of recent 100X multiples means we’re living 2021 all over again, why that’s led people to deploy but not fundraise, and the level of curiosity you need to be an exceptional LP. This episode of Origins is supported by Sydecar. Visit https://sydecar.io/origins-podcast to learn more. Learn more about Sapphire Partners: https://sapphireventures.com/sapphire-partners Learn more about OpenLP: https://openlp.vc Learn more about Asylum Ventures: https://asylum.vc Learn more about Slipstream: https://www.slipstreaminvestors.com/ For a monthly roundup of the latest venture insights, including the newest Origins episodes, subscribe to the OpenLP newsletter – delivered straight to your inbox: https://subscribe.openlp.vc Sydecar, Inc. (“Sydecar”) has acted as a financial sponsor within this Origins podcast. Sapphire Ventures, LLC (“Sapphire”) is not affiliated with or invested in Sydecar. CHAPTERS: 0:00 Welcome to Origins 2:01 Did We Learn Nothing From 2021? 4:09 High Prices, Quick Deployment 6:31 Venture Lives On Bubbles…
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Origins - Inside Venture Capital, Hosted by a GP and an LP

1 Fundraising as a Fund of Funds with Alex Edelson 49:23
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Alex Edelson’s Slipstream is a fund of funds that focuses on firms that are “difficult to find, evaluate and access.” Together with Beezer Clarkson, Partner at Sapphire Partners, and Nick Chirls, Partner at Asylum Ventures, Alex unpacks his strategy of investing in funds he believes can outperform, how to raise capital as an LP, and how to remain competitive against LPs investing in more established firms. The three of them also dig into a recent blog post by Beezer titled “Is Venture Broken?” - which explores the role of mega-funds in the early-stage market. You can read that here . This episode of Origins is supported by Sydecar. Visit https://sydecar.io/origins-podcast to learn more. Learn more about Sapphire Partners: https://sapphireventures.com/sapphire-partners Learn more about OpenLP: https://openlp.vc Learn more about Asylum Ventures: https://asylum.vc Learn more about Slipstream: https://slipstreaminvestors.com For a monthly roundup of the latest venture insights, including the newest Origins episodes, subscribe to the OpenLP newsletter – delivered straight to your inbox: https://subscribe.openlp.vc Sydecar, Inc. (“Sydecar”) has acted as a financial sponsor within this Origins podcast. Sapphire Ventures, LLC (“Sapphire”) is not affiliated with or invested in Sydecar. CHAPTERS: 0:00-Welcome to Origins 2:59-Why Start a Fund of Funds? 7:39-How Do LPs Raise Capital? 16:56-I’m the LP I Wanted to Work With As a GP 21:17-What Is Similar & Different Between Now and 2021? 30:41-What Is an Advantage One Day Is Table Stakes the Next 34:18-You Don’t Need a Big Winner to Have An Amazing Small Fund 39:08-Is Venture Broken?…
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Origins - Inside Venture Capital, Hosted by a GP and an LP

1 Minisode: Curiosity, Chemistry, and Keeping Relevance Across the Partnership 14:10
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Origins host Beezer Clarkson, LP at Sapphire Partners and co-founder of OpenLP is rejoined by Nick Chirls, GP at Asylum Ventures to unpack her recent conversation with Sunil Dhaliwal and Mike Dauber of Amplify Partners. They discuss partner dynamics, the importance of maintaining relevance for the long haul, and the different ways curiosity can show up. Plus, Nick & Beezer dig into whether they count as extroverts at work and introverts everywhere else. Learn more about Sapphire Partners: https://sapphireventures.com/sapphire-partners Learn more about OpenLP: https://openlp.vc Learn more about Asylum Ventures: https://asylum.vc Learn more about Amplify: https://amplifypartners.com Subscribe to the OpenLP newsletter for a monthly roundup of the latest venture insights, including the newest Origins episodes, delivered straight to your inbox. CHAPTERS: 0:00 Welcome to Origins 2:18 ”I’m Not Gonna Be a Solo GP Forever” 6:07 Pushing Decision Making to the Edge at Amplify 9:24 How Are You Relevant Five Years From Now? 13:24 Investors: Introverts or Extroverts?…
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Origins - Inside Venture Capital, Hosted by a GP and an LP

1 Backing Outliers in Venture with Sunil Dhaliwal & Mike Dauber 41:13
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Sunil Dhaliwal founded Amplify in 2012, and was joined by his longtime friend and colleague Mike Dauber in 2014. Beginning as one of the first solo GP, early-stage, sector-focused funds, Amplify has now grown to a team of 9 partners investing in the next generation of applications tools and platforms for developers, data teams, and ML engineers focused on AI, cloud infrastructure, and data security. Mike and Sunil sit down with Beezer Clarkson, Partner at Sapphire Partners, to discuss their strategy of building for outliers, shaping founders into leaders, and making it easy for their GPs to back non-consensus companies. They also unpack their recent $900 million raise and their first dedicated biotech fund, Amplify Bio. Learn more about Sapphire Partners: https://sapphireventures.com/sapphire-partners Learn more about OpenLP: https://openlp.vc Learn more about Asylum Ventures: https://asylum.vc Learn more about Amplify: https://amplifypartners.com For a monthly roundup of the latest venture insights, including the newest Origins episodes, subscribe to the OpenLP newsletter – delivered straight to your inbox: subscribe.openlp.vc CHAPTERS: 0:00 Welcome to Origins 2:17 The Origins of Amplify 5:21 Eliminating the Need for “Mr. Business” 10:25 Building Amplify for Outliers 25:08 Being Technical VCs in the Age of AI 28:47 Amplify Bio 36:19 Has Venture Actually Changed At All?…
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Origins - Inside Venture Capital, Hosted by a GP and an LP

1 Minisode: Are Major Incumbents Finally at Risk in the Age of AI? 7:30
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Origins hosts Nick Chirls, GP at Asylum Ventures and Beezer Clarkson, LP at Sapphire Partners and co-founder of OpenLP, dig into their recent conversation with Will Manidis, SVP at Veradigm AI. They discuss the risks AI introduces to tech incumbents, and its potential to reshape both the healthcare system and improve patient outcomes. Learn more about Sapphire Partners: https://sapphireventures.com/sapphire-partners Learn more about OpenLP: https://openlp.vc Learn more about Asylum Ventures: https://asylum.vc Learn more about Veradigm: https://veradigm.com/ Subscribe to the OpenLP newsletter for a monthly roundup of the latest venture insights, including the newest Origins episodes, delivered straight to your inbox. CHAPTERS : (0:00) Welcome to Origins (1:41) Humor in Venture? (3:17) Are Incumbents Finally At Risk? (6:25) How Extremely Online is Nick?…
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Origins - Inside Venture Capital, Hosted by a GP and an LP

1 Merchant Banks: Venture’s Next Act with Will Manidis 43:54
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Before he sold his company to Veradigm, Will Manidis’s Science.io developed an AI model that allowed doctors to translate mountains of medical documents into usable data to improve patient outcomes. Today Will is the SVP of AI at Veradigm, and he sits down with Nick and Beezer to discuss how AI is impacting healthcare, how we can develop health systems with better outcomes, and what the future of venture might look like when compared to traditional merchant banking. Learn more about Sapphire Partners: https://sapphireventures.com/sapphire-partners Learn more about OpenLP: https://openlp.vc Learn more about Asylum Ventures: https://asylum.vc Learn more about Veradigm: https://veradigm.com/ For a monthly roundup of the latest venture insights, including the newest Origins episodes, subscribe to the OpenLP newsletter – delivered straight to your inbox: https://subscribe.openlp.vc CHAPTERS: (0:00) Welcome to Origins (2:01) Human vs. AI Content (Specifically Podcasts) (6:18) AI And the Future of Healthcare (17:55) Is Merchant Banking Venture’s Future? (25:17) When Does Venture Break? (32:42) “The Only Thing We Should Care About is the Shape of the Return Curve.” (37:24) “The Constraint Is No Longer Capital.”…
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Origins - Inside Venture Capital, Hosted by a GP and an LP

1 Minisode: Innovation Energy And the Future of Biotech 11:24
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Origins hosts Nick Chirls, GP at Asylum Ventures and Beezer Clarkson, LP at Sapphire Partners and co-founder of OpenLP, unpack their conversation with Zach Weinberg, Co-Founder and CEO of Curie.Bio. They discuss the “innovation energy” that drives new breakthroughs and take a closer look at Sapphire’s approach to biotech investing. Learn more about Sapphire Partners: https://sapphireventures.com/sapphire-partners Learn more about OpenLP: https://openlp.vc Learn more about Asylum Ventures: https://asylum.vc Learn more about Curie.Bio: https://curie.bio Subscribe to the OpenLP newsletter for a monthly roundup of the latest venture insights, including the newest Origins episodes, delivered straight to your inbox. CHAPTERS : 0:00 - Welcome to Origins 1:28 -Building Something That Wouldn’t Exist Otherwise 4:27 - What’s Sapphire Doing in BioTech? 8:38 - The Market & BioTech 10:05 - "Vitamin O"…
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Origins - Inside Venture Capital, Hosted by a GP and an LP

1 Building The YC of Biotech with Zach Weinberg 58:13
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Zach Weinberg, co-founder and CEO of Curie.Bio, is redefining early-stage biotech investing with an operator’s mindset and a founder-first philosophy. His approach combines funding with operational support and direct access to world-class drug hunters to dramatically increase odds of success. Today, Zach sits down with Nick Chirls, GP at Asylum Ventures and Beezer Clarkson, LP at Sapphire Partners to discuss the massive risk associated with traditional therapeutics startups, how pairing a drug discovery partner with a seed investor solves those inefficiencies, and how biotech, the global economy and the political landscape are all closely connected. Learn more about Sapphire Partners: https://sapphireventures.com/sapphire-partners Learn more about OpenLP: https://openlp.vc Learn more about Asylum Ventures: https://asylum.vc Learn more about Curie.Bio: https://curie.bio For a monthly roundup of the latest venture insights, including the newest Origins episodes, subscribe to the OpenLP newsletter – delivered straight to your inbox: https://subscribe.openlp.vc CHAPTERS: (0:00) Welcome to Origins (5:08) Was Hunter High School Harder Than Penn? (10:22) Transitioning From SaaS to Biotech (20:55) Why Is Building a Biotech Venture Firm So Hard? (27:55) Building Curie.Bio (32:24) Zach on Drug Discovery (43:12) Biotech in China (49:42) AI in Biotech (54:51) "The Manhattan Project of Biology"…
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Origins - Inside Venture Capital, Hosted by a GP and an LP

1 Minisode: How Novel Strategies Become the Venture Industry’s Standard 13:56
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Origins hosts Nick Chirls, GP at Asylum Ventures and Beezer Clarkson, LP at Sapphire Partners and co-founder of OpenLP, unpack their conversation with Theory Ventures’ Tomasz Tunguz, discussing how strategies that once set firms apart – like pre-seed or founder-centric investing – become industry standards over time. They dive deep on counter-positioning, adaptability, and the power of differentiation in today’s venture world. CHAPTERS : (0:00) Welcome to Origins (1:14) Is Tomasz an n=1? (5:51) How Do Firms Stay Relevant? (9:12) Do Founders Like Counter-Positioning? (11:50) Who Is An Emerging Manager/Nick’s Next Career Learn more about Sapphire Partners: https://sapphireventures.com/sapphire-partners Learn more about OpenLP: https://openlp.vc Learn more about Asylum Ventures: https://asylum.vc Learn more about Theory Ventures: https://theory.ventures Subscribe to the OpenLP newsletter for a monthly roundup of the latest venture insights, including the newest Origins episodes, delivered straight to your inbox.…
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Origins - Inside Venture Capital, Hosted by a GP and an LP

1 AI Agents Will Supercharge the Future of VC with Tomasz Tunguz 40:25
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Tomasz Tunguz, Founder of Theory Ventures, is widely recognized for his analytical approach to venture investing. Now, he’s building Theory with a philosophy rooted in research and data-driven decision-making. Tomasz sits down with Nick Chirls, General Partner at Asylum Ventures and Beezer Clarkson, LP at Sapphire Partners and co-founder of OpenLP, to discuss spinouts and succession in established firms and the value of running high-risk, high-reward experiments at specialist firms like Theory. Tomasz also shares his belief that investors will need to adapt to a future where asking the right questions of LLMs will be critical for success. CHAPTERS: (0:00) Welcome to Origins (4:05) Why Are So Many People Leaving Top Firms? (12:15) Getting the Probabilities On Your Side (16:01) Building Highly Concentrated Portfolios (17:33) Lessons Learned in Fund One (21:37) Tomasz’s Brand v. Theory’s Brand (27:15) Using Tech at the Core of Theory (34:31) Asking the Right Questions in AI (36:56) Predictions for 2026 Learn more about Sapphire Partners: https://sapphireventures.com/sapphire-partners Learn more about OpenLP: https://openlp.vc Learn more about Asylum Ventures: https://asylum.vc Learn more about Theory Ventures: https://theory.ventures Subscribe to the OpenLP newsletter for a monthly roundup of the latest venture insights, including the newest Origins episodes, delivered straight to your inbox.…
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