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84. Deep Mutational Scanning and How to Investigate Protein Behaviour (with Isabelle Zane)
Manage episode 443310587 series 3412534
In this week's episode we are joined by Isabelle Zane, a PhD student at the Wellcome Sanger Institute in Cambridge who is investigating the link between genetic mutations and protein function in the Lehner & Parts labs. We discuss a novel technology- deep mutational scanning- which is used to screen how single gene mutations influence the structure and/or function of proteins, thereby testing the relationship between genotype and phenotype. We also discuss methods used to study protein dynamics, including nuclear magnetic resonance (NMR) spectroscopy, X-ray crystallography, and more! Listen to find out more about the fascinating ways in which we can interrogate the relationship between DNA and the proteins they encode.
You can find Isabelle's cartoon creations about life and people in the lab on her twitter @isabellease
Today’s episode was made possible thanks to the support of the Biochemical Society public engagement fund. We would like to thank the Biochemical Society for the generous grant supporting Science Communication initiatives like these. https://www.google.com/search?client=safari&rls=en&q=the+biochemical+society&ie=UTF-8&oe=UTF-8
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We hope you enjoy the episode! Please feel free to share with your friends and family, it means a lot to us🤍
Neuroverse Website
https://neuroversepod.com
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https://neuroversepod.teemill.com
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https://anchor.fm/neuroverse9
Support us!
https://ko-fi.com/neuroverse
Twitter: @neuroverse_pod
https://twitter.com/neuroverse_pod?s=21&t=KvAEuwGNKFQ9IPKlL7NTEg
Instagram: @Neuroverse_pod
https://instagram.com/neuroverse_pod?igshid=YmMyMTA2M2Y=
Help us improve our podcast by giving us some feedback!
91 episode
Manage episode 443310587 series 3412534
In this week's episode we are joined by Isabelle Zane, a PhD student at the Wellcome Sanger Institute in Cambridge who is investigating the link between genetic mutations and protein function in the Lehner & Parts labs. We discuss a novel technology- deep mutational scanning- which is used to screen how single gene mutations influence the structure and/or function of proteins, thereby testing the relationship between genotype and phenotype. We also discuss methods used to study protein dynamics, including nuclear magnetic resonance (NMR) spectroscopy, X-ray crystallography, and more! Listen to find out more about the fascinating ways in which we can interrogate the relationship between DNA and the proteins they encode.
You can find Isabelle's cartoon creations about life and people in the lab on her twitter @isabellease
Today’s episode was made possible thanks to the support of the Biochemical Society public engagement fund. We would like to thank the Biochemical Society for the generous grant supporting Science Communication initiatives like these. https://www.google.com/search?client=safari&rls=en&q=the+biochemical+society&ie=UTF-8&oe=UTF-8
---
We hope you enjoy the episode! Please feel free to share with your friends and family, it means a lot to us🤍
Neuroverse Website
https://neuroversepod.com
Merchandise:
https://neuroversepod.teemill.com
Podcast directory
https://anchor.fm/neuroverse9
Support us!
https://ko-fi.com/neuroverse
Twitter: @neuroverse_pod
https://twitter.com/neuroverse_pod?s=21&t=KvAEuwGNKFQ9IPKlL7NTEg
Instagram: @Neuroverse_pod
https://instagram.com/neuroverse_pod?igshid=YmMyMTA2M2Y=
Help us improve our podcast by giving us some feedback!
91 episode
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