PT Inquest is an online journal club. Hosted by Jason Tuori, Megan Graham, and Chris Juneau, the show looks at an article every week and discusses how it applies to current physical therapy practice.
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The Link Between Proteins Alzheimer’s and Parkinson’s Diseases
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Manage episode 446202531 series 2565168
Konten disediakan oleh UCTV. Semua konten podcast termasuk episode, grafik, dan deskripsi podcast diunggah dan disediakan langsung oleh UCTV atau mitra platform podcast mereka. Jika Anda yakin seseorang menggunakan karya berhak cipta Anda tanpa izin, Anda dapat mengikuti proses yang diuraikan di sini https://id.player.fm/legal.
Proteins are large biomolecules that play critical roles in a host of cellular processes, from cell signaling to regulating the immune system. However, these life-giving proteins can form toxic aggregate species that have been linked to several neurodegenerative diseases, including Alzheimer’s Disease and Parkinson’s Disease. In this program, UC Santa Barbara professor Joan-Emma Shea discusses the tau protein as a model system to study neurodegeneration. Shea says this protein plays a functional role in stabilizing microtubules in brain cells, but it can also self-assemble to form amyloid fibrils (large “clumps” of Tau proteins). There are several neurodegenerative diseases linked to tau assembly, including Alzheimer’s Disease, Pick’s Disease, and chronic traumatic encephalopathy, and they are collectively known as tauopathies. Shea discusses new insights into tauopathies and targets for therapeutics. Series: "GRIT Talks" [Science] [Show ID: 40083]
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122 episode
MP4•Beranda episode
Manage episode 446202531 series 2565168
Konten disediakan oleh UCTV. Semua konten podcast termasuk episode, grafik, dan deskripsi podcast diunggah dan disediakan langsung oleh UCTV atau mitra platform podcast mereka. Jika Anda yakin seseorang menggunakan karya berhak cipta Anda tanpa izin, Anda dapat mengikuti proses yang diuraikan di sini https://id.player.fm/legal.
Proteins are large biomolecules that play critical roles in a host of cellular processes, from cell signaling to regulating the immune system. However, these life-giving proteins can form toxic aggregate species that have been linked to several neurodegenerative diseases, including Alzheimer’s Disease and Parkinson’s Disease. In this program, UC Santa Barbara professor Joan-Emma Shea discusses the tau protein as a model system to study neurodegeneration. Shea says this protein plays a functional role in stabilizing microtubules in brain cells, but it can also self-assemble to form amyloid fibrils (large “clumps” of Tau proteins). There are several neurodegenerative diseases linked to tau assembly, including Alzheimer’s Disease, Pick’s Disease, and chronic traumatic encephalopathy, and they are collectively known as tauopathies. Shea discusses new insights into tauopathies and targets for therapeutics. Series: "GRIT Talks" [Science] [Show ID: 40083]
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122 episode
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