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467: Prion Pivots Productive Pathways
Manage episode 315843068 series 1567470
This episode: Prions in yeast can allow better adaptation to changing conditions!
Download Episode (9.5 MB, 13.9 minutes) Show notes: Microbe of the episode: Hepatovirus F
News item Takeaways Prions can be deadly. They're misshapen proteins that cause a cascade of misfolding of similar proteins if they get into the nervous system, resulting in neurodegeneration in mammals. But in other organisms, they are not always so scary; some fungi use prions to regulate their behavior in varying conditions. In this study, a prion allows yeast to switch between a fast-growing lifestyle with shorter reproductive lifespan that can be beneficial in conditions where nutrients are often plentiful, and a slower-growing but more enduring lifestyle that helps in more scarce conditions. Journal Paper: Garcia DM, Campbell EA, Jakobson CM, Tsuchiya M, Shaw EA, DiNardo AL, Kaeberlein M, Jarosz DF. 2021. A prion accelerates proliferation at the expense of lifespan. eLife 10:e60917.Other interesting stories:
Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening!
Subscribe: Apple Podcasts, Google Podcasts, Android, or RSS. Support the show at Patreon, or check out the show at Twitter or Facebook.
152 episode
Manage episode 315843068 series 1567470
This episode: Prions in yeast can allow better adaptation to changing conditions!
Download Episode (9.5 MB, 13.9 minutes) Show notes: Microbe of the episode: Hepatovirus F
News item Takeaways Prions can be deadly. They're misshapen proteins that cause a cascade of misfolding of similar proteins if they get into the nervous system, resulting in neurodegeneration in mammals. But in other organisms, they are not always so scary; some fungi use prions to regulate their behavior in varying conditions. In this study, a prion allows yeast to switch between a fast-growing lifestyle with shorter reproductive lifespan that can be beneficial in conditions where nutrients are often plentiful, and a slower-growing but more enduring lifestyle that helps in more scarce conditions. Journal Paper: Garcia DM, Campbell EA, Jakobson CM, Tsuchiya M, Shaw EA, DiNardo AL, Kaeberlein M, Jarosz DF. 2021. A prion accelerates proliferation at the expense of lifespan. eLife 10:e60917.Other interesting stories:
Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening!
Subscribe: Apple Podcasts, Google Podcasts, Android, or RSS. Support the show at Patreon, or check out the show at Twitter or Facebook.
152 episode
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