TWiV 1092: Clinical update with Dr. Daniel Griffin

This Week in Virology

In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2 before discussing new vaccine guidelines released by the advisory committee on immunization practices, and reviews the CDC guidelines for quarantine/ isolation following SARS-CoV-2 infection, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, the role of IFN-g in long COVID, if the brain-blood-barrier is compromised in long COVID, meaning of persistent community SARS-CoV-2 RNA findings, and the effects of hyperbaric oxygen on post COVID neurocognition.

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Links for this episode

• Respiratory disease surveillance (CDC)
• RSV surveillance (CDC)
• RSV national trend (CDC)
• RSV vaccination stats (CIDRAP)
• Influenza/flu surveillance (CDC)
• Influenza/flu map (CDC)
• COVID-19 hospital admissions (CDC)
• COVID-19 national trend (CDC)
• COVID-19 wastewater testing (biobot)
• Variant tracker (CDC)
• Variant hospital admissions (CDC)
• ACIP COVID vaccination for seniors recommendations (CIDRAP)
• Additional vaccine doses for older adults (CDC)
• Evidence based advice from the ACIP (CDC)
• State mandates did NOT influence primary vaccination rates only boosters (PNAS)
• No nOPV2? (CDC)
• CDC Quarantine guidelines (CDC)
• To rebound or to not rebound (MMWR)
• Know your COVID-19 tools (ESMED)
• How to pay for Paxlovid (PAXCESS)
• Molnupiravir safety and efficacy (JMV)
• Molunpiravir plus antibody therapy for at-risk outpatients (Nat Comm)
• Convalescent plasma recommendation for immunocompromised (IDSociety)
• Steroids, dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Spontaneous release of IFN-g in Long COVID (Science Advances)
• Blood-brain-barrier compromise in long COVID associated cognitive impairment (Nat Neuroscience)
• Persistent community SARS-CoV-2 RNA (Nature)
• Hyberbaric oxygen therapy improves post COVID neurocognition (Scientific Reports)
• Medical study questionnaire, the SHORT form (Brandeis)
• Long term effects of hyperbaric oxygen post COVID (Scientific Reports)
• Contribute to our ASTMH fundraiser at PWB
• Letters read on TWiV 1092
• Dr. Griffin’s COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [e-mail]