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Épisode 46 | COVID-19 : Thrombocytopénie thrombotique immunitaire et vaccins

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Konten disediakan oleh Trait pharmacien. Semua konten podcast termasuk episode, grafik, dan deskripsi podcast diunggah dan disediakan langsung oleh Trait pharmacien atau mitra platform podcast mereka. Jika Anda yakin seseorang menggunakan karya berhak cipta Anda tanpa izin, Anda dapat mengikuti proses yang diuraikan di sini https://id.player.fm/legal.
La thrombocytopénie thrombotique immunitaire induite par certains vaccins contre la COVID, dont ceux produits par AstraZeneca et Johnson et Johnson, a fait couler beaucoup d’encre dans l’actualité. Quels sont les risques réels, les symptômes à surveiller et la conduite à adopter pour le pharmacien ? Pierre Lemieux, pharmacien au CIUSSS de la Mauricie et du Centre du Québec, a bien voulu nous éclairer sur le sujet. Références : 1. Thrombocytopénie immunitaire prothrombotique induite par le vaccin – TIPIV (ou TTIV) en contexte de vaccination contre la COVID-19. INSPQ. Version du 19 avril 2021 https://publications.msss.gouv.qc.ca/msss/fichiers/directives-covid/dgaumip-030-rev1_thrombocytopenie-tipiv-%20vaccin-covid-19.pdf 2. Comité consultatif national de l’immunisation (CCNI). Recommandations sur l’utilisation des vaccins contre la COVID-19. Mise à jour du 23 avril 2021. https://www.canada.ca/content/dam/phac-aspc/documents/services/immunization/national-advisory-committee-on-immunization-naci/recommendations-use-covid-19-vaccines/recommandations-utilisation-vaccins-covid-19-fr.pdf 3. Mahase E. AstraZeneca vaccine: Blood clots are “extremely rare” and benefits outweigh risks, regulators conclude BMJ 2021; 373 :n931 doi:10.1136/bmj.n931 https://www.bmj.com/content/373/bmj.n931 4. Les thromboses (caillots sanguins) et les vaccins contre la COVID-19. Thrombose canada Foire aux questions. Avril 2021. https://thrombosiscanada.ca/wp-uploads/uploads/2021/04/COVID-19-vaccine-and-Thrombosis-FAQs-April-2-2021_FR.pdf 5. Tacquet et al. Cerebral venous thrombosis: a retrospective cohort study of 513,284 confirmed COVID-19 cases and a comparison with 489,871 people receiving a COVID-19 mRNA vaccine, preprint https://osf.io/a9jdq/ 6. Katsanos et al. The Impact of SARS‐CoV‐2 on Stroke Epidemiology and Care: A Meta‐Analysis Ann Neurol. 2020 Dec 9 : 10.1002/ana.25967 (2020) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753413/ ; 7. Andreas Greinacher et coll. Anti-SARS-CoV-2 Spike Protein and Anti-Platelet Factor 4 Antibody Responses Induced by COVID-19 Disease and ChAdOx1 nCov-19 vaccination, 09 April 2021, PREPRINT (Version 1) available at Research Square https://www.researchsquare.com/article/rs-404769/v1 8. Scully et coll. Pathologic Antibodies to Platelet Factor 4 after ChAdOx1 nCoV-19 Vaccination. NEJM April 16, 2021. DOI: 10.1056/NEJMoa2105385 https://www.nejm.org/doi/full/10.1056/NEJMoa2105385 9. Gowthami M et coll. Heparin-Induced Thrombocytopenia A Focus on Thrombosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 2021;41:141–152 https://www.ahajournals.org/doi/pdf/10.1161/ATVBAHA.120.315445 10. CDC. Coronavirus Disease 2019 (COVID-19) Vaccines https://www.cdc.gov/vaccines/acip/meetings/slides-2021-04-23.html 11. The Gamalaya Center Statement https://sputnikvaccine.com/newsroom/pressreleases/the-gamaleya-center-statement/ 12. Greinacher A. et coll. Towards Understanding ChAdOx1 nCov-19 Vaccine-induced Immune Thrombotic Thrombocytopenia (VITT). 2021. Preprint. https://assets.researchsquare.com/files/rs-440461/v1/8eabf306-6fd4-4a89-a7a3-8f4d06c89a55.pdf
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87 episode

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iconBagikan
 
Manage episode 292147318 series 1936278
Konten disediakan oleh Trait pharmacien. Semua konten podcast termasuk episode, grafik, dan deskripsi podcast diunggah dan disediakan langsung oleh Trait pharmacien atau mitra platform podcast mereka. Jika Anda yakin seseorang menggunakan karya berhak cipta Anda tanpa izin, Anda dapat mengikuti proses yang diuraikan di sini https://id.player.fm/legal.
La thrombocytopénie thrombotique immunitaire induite par certains vaccins contre la COVID, dont ceux produits par AstraZeneca et Johnson et Johnson, a fait couler beaucoup d’encre dans l’actualité. Quels sont les risques réels, les symptômes à surveiller et la conduite à adopter pour le pharmacien ? Pierre Lemieux, pharmacien au CIUSSS de la Mauricie et du Centre du Québec, a bien voulu nous éclairer sur le sujet. Références : 1. Thrombocytopénie immunitaire prothrombotique induite par le vaccin – TIPIV (ou TTIV) en contexte de vaccination contre la COVID-19. INSPQ. Version du 19 avril 2021 https://publications.msss.gouv.qc.ca/msss/fichiers/directives-covid/dgaumip-030-rev1_thrombocytopenie-tipiv-%20vaccin-covid-19.pdf 2. Comité consultatif national de l’immunisation (CCNI). Recommandations sur l’utilisation des vaccins contre la COVID-19. Mise à jour du 23 avril 2021. https://www.canada.ca/content/dam/phac-aspc/documents/services/immunization/national-advisory-committee-on-immunization-naci/recommendations-use-covid-19-vaccines/recommandations-utilisation-vaccins-covid-19-fr.pdf 3. Mahase E. AstraZeneca vaccine: Blood clots are “extremely rare” and benefits outweigh risks, regulators conclude BMJ 2021; 373 :n931 doi:10.1136/bmj.n931 https://www.bmj.com/content/373/bmj.n931 4. Les thromboses (caillots sanguins) et les vaccins contre la COVID-19. Thrombose canada Foire aux questions. Avril 2021. https://thrombosiscanada.ca/wp-uploads/uploads/2021/04/COVID-19-vaccine-and-Thrombosis-FAQs-April-2-2021_FR.pdf 5. Tacquet et al. Cerebral venous thrombosis: a retrospective cohort study of 513,284 confirmed COVID-19 cases and a comparison with 489,871 people receiving a COVID-19 mRNA vaccine, preprint https://osf.io/a9jdq/ 6. Katsanos et al. The Impact of SARS‐CoV‐2 on Stroke Epidemiology and Care: A Meta‐Analysis Ann Neurol. 2020 Dec 9 : 10.1002/ana.25967 (2020) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753413/ ; 7. Andreas Greinacher et coll. Anti-SARS-CoV-2 Spike Protein and Anti-Platelet Factor 4 Antibody Responses Induced by COVID-19 Disease and ChAdOx1 nCov-19 vaccination, 09 April 2021, PREPRINT (Version 1) available at Research Square https://www.researchsquare.com/article/rs-404769/v1 8. Scully et coll. Pathologic Antibodies to Platelet Factor 4 after ChAdOx1 nCoV-19 Vaccination. NEJM April 16, 2021. DOI: 10.1056/NEJMoa2105385 https://www.nejm.org/doi/full/10.1056/NEJMoa2105385 9. Gowthami M et coll. Heparin-Induced Thrombocytopenia A Focus on Thrombosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 2021;41:141–152 https://www.ahajournals.org/doi/pdf/10.1161/ATVBAHA.120.315445 10. CDC. Coronavirus Disease 2019 (COVID-19) Vaccines https://www.cdc.gov/vaccines/acip/meetings/slides-2021-04-23.html 11. The Gamalaya Center Statement https://sputnikvaccine.com/newsroom/pressreleases/the-gamaleya-center-statement/ 12. Greinacher A. et coll. Towards Understanding ChAdOx1 nCov-19 Vaccine-induced Immune Thrombotic Thrombocytopenia (VITT). 2021. Preprint. https://assets.researchsquare.com/files/rs-440461/v1/8eabf306-6fd4-4a89-a7a3-8f4d06c89a55.pdf
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