Brian Freeman, MD - Burn More Calories

Angel Invest Boston

Angel Scale Biotech: Learn More

Brian Freeman, MD, co-founded Energesis to help overweight people lose weight by growing their energy-burning brown fat. Experiments in mice have shown this approach works with GLP-1 drugs such as Wegovy in accentuating weight loss. Great chat with a compelling repeat founder.

Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.

Highlights:

• Sal Daher Introduces Brian Freeman
• Energesis: The Problem it's Solving
• "... What we're doing is we're acting on those cells and basically nudging them to make more mature brown fat cells, so that the mass of the brown fat cells increases..."
• "... That's pretty much it. We're trying to recapitulate cold exposure in a pill. That's right..."
• "... one of the issues with weight loss due to, let's call it caloric restriction ... The body doesn't take it lightly because we've evolved not to starve, right? ... The normal physiologic response to that is to reduce metabolic rate. That makes it harder and harder to lose weight as your weight goes down, and it makes it very difficult to keep that weight off..."
• Further Thoughts on Energesis
• Brian's Entrepreneurial Journey
• "... What if you could magically make everybody in America lean overnight, think of what that would do to healthcare costs. It would be reduced by at least two-thirds..."

Topics: biotech, discovering entrepreneurship, product, founding story