Episode 21. Newly Diagnosed Mantle Cell Lymphoma

Blood Cancer Talks

In this episode, we delve into the management of newly diagnosed mantle cell lymphoma with Dr. Martin Dreyling. Here the shownotes:

2:11 How to diagnose mantle cell lymphoma (MCL)?

6:51 Clinical manifestations of mantle cell lymphoma

7:52 How to manage leukemic variant of MCL?

12:08 Is Watch-and-Wait reasonable in selected cases of nodal MCL with low Ki-67?

17:21 Overview on treatment of newly diagnosed MCL

19:03 Are all cytarabine-based regimens for MCL created equally?

RCT of Autologous Transplantation in MCL: https://pubmed.ncbi.nlm.nih.gov/15591112/

21:39 In a world without upfront ibrutinib access as per TRIANGLE trial, do all fit patients with MCL need consolidation with auto-transplant?

22:44 How to approach unfit patients with newly diagnosed MCL?

RCT of bortezomib-based therapy (VR-CAP) in newly diagnosed MCL: https://pubmed.ncbi.nlm.nih.gov/25738670/

24:57 SHINE Trial-RCT of Ibrutinib plus BR in newly diagnosed MCL: https://pubmed.ncbi.nlm.nih.gov/35657079/

30:38 TRIANGLE Trial-RCT of upfront ibrutinib with or without auto-transplant in newly diagnosed MCL:

https://ashpublications.org/blood/article/134/Supplement_1/2816/423504

43:01: Does Allo-Transplant have any role in MCL?

44:08: What are the likely next breakthroughs in newly diagnosed MCL space?