First AI Antibody In Humans with Aulos' Aron Knickerbocker

Business Of Biotech

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Data drives decision-making at Aulos Bioscience. It's also driven the career trajectory of its CEO. On this week's episode of the Business of Biotech podcast, we get an introspective walk through Aron Kinickerbocker's strategically-orchestrated career path, from his early days in the labs at Bristol-Myers Squibb and Genentech to his leadership of Aulos Bioscience, a company that boasts the first AI-generated antibody in human clinical trials. We explore Aulos' innovative IL-2 antibody and the role AI played in its highly-targeted and toxicity-reducing design, and we do it in pragmatic fashion — Aron's not about the AI hype, he's about the AI data — and in its Phase 1/2 clinical trial, the data is looking pretty good.

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Chapter

1. Bioprocess Online's BioExpo Live (00:00:00)

2. Career Decisions in Biopharma Transition (00:08:26)

3. Building a Biopharma Career Journey (00:17:10)

4. Rising Biopharma Ventures and Courageous Decision-Making (00:25:54)

5. Innovations in IL-2 Antibody Design (00:42:30)

6. AI Influence on IL-2 Antibody Design (00:48:19)

7. Update on Phase 2 Clinical Trials (01:01:39)