NEJM at AHA — Left Atrial Appendage Closure after Ablation for Atrial Fibrillation

NEJM Interviews

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Understanding the Elegant Math Behind Modern Machine Learning 1:14:43

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Artificial intelligence is evolving at an unprecedented pace—what does that mean for the future of technology, venture capital, business, and even our understanding of ourselves? Award-winning journalist and writer Anil Ananthaswamy joins us for our latest episode to discuss his latest book Why Machines Learn: The Elegant Math Behind Modern AI . Anil helps us explore the journey and many breakthroughs that have propelled machine learning from simple perceptrons to the sophisticated algorithms shaping today’s AI revolution, powering GPT and other models. The discussion aims to demystify some of the underlying mathematical concepts that power modern machine learning, to help everyone grasp this technology impacting our lives–even if your last math class was in high school. Anil walks us through the power of scaling laws, the shift from training to inference optimization, and the debate among AI’s pioneers about the road to AGI—should we be concerned, or are we still missing key pieces of the puzzle? The conversation also delves into AI’s philosophical implications—could understanding how machines learn help us better understand ourselves? And what challenges remain before AI systems can truly operate with agency? If you enjoy this episode, please subscribe and leave us a review on your favorite podcast platform. Sign up for our newsletter at techsurgepodcast.com for exclusive insights and updates on upcoming TechSurge Live Summits. Links: Read Why Machines Learn, Anil’s latest book on the math behind AI https://www.amazon.com/Why-Machines-Learn-Elegant-Behind/dp/0593185749 Learn more about Anil Ananthaswamy’s work and writing https://anilananthaswamy.com/ Watch Anil Ananthaswamy’s TED Talk on AI and intelligence https://www.ted.com/speakers/anil_ananthaswamy Discover the MIT Knight Science Journalism Fellowship that shaped Anil’s AI research https://ksj.mit.edu/ Understand the Perceptron, the foundation of neural networks https://en.wikipedia.org/wiki/Perceptron Read about the Perceptron Convergence Theorem and its significance https://www.nature.com/articles/323533a0…

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Eric Rubin is the Editor-in-Chief of the Journal. Jane Leopold is a Deputy Editor of the Journal. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. E.J. Rubin, J. Leopold, and S. Morrissey. NEJM at AHA — Left Atrial Appendage Closure after Ablation for Atrial Fibrillation. N Engl J Med. DOI: 10.1056/NEJMe2414475.

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NEJM Interviews

NEJM at AHA — Left Atrial Appendage Closure after Ablation for Atrial Fibrillation

NEJM Interviews

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877 episode

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NEJM Interviews

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NEJM Interview: Sara Gerke on the potential for genetic data and other personal information to be included in business transactions in the United States. 7:00

1 day yang lalu7:00

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Sara Gerkeis an associate professor of law at the University of Illinois Urbana-Champaign. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. S. Gerke, M.B. Jacoby, and I.G. Cohen. Bankruptcy, Genetic Information, and Privacy — Selling Personal Information. N Engl J Med 2025;392:937-939.…

NEJM Interviews

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NEJM Outbreaks Update — H5N1 19:05

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19:05

In this NEJM Outbreaks Update, Editor-in-Chief Eric Rubin and Deputy Editor Lindsey Baden are joined by veterinarian and virologist Yoshihiro Kawaoka to discuss avian influenza and its current impact on chickens, cows, cats, and humans. Eric Rubin is the Editor-in-Chief of the Journal. Lindsey Baden is a Deputy Editor of the Journal. Yoshihiro Kawaoka is a veterinarian and virologist and a professor at the University of Wisconsin-Madison and the University of Tokyo. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. E.J. Rubin and Others. NEJM Outbreaks Update — H5N1. N Engl J Med. DOI: 10.1056/NEJMe2502267.…

NEJM Interviews

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NEJM Interview: John Kelly on shifts in approaches for addressing substance use disorder. 10:41

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John Kelly is the director of the Recovery Research Institute at Massachusetts General Hospital and a professor of psychiatry in addiction medicine at Harvard Medical School. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. J.F. Kelly, N.D. Volkow, and H.K. Koh. The Changing Approach to Addiction — From Incarceration to Treatment and Recovery Support. N Engl J Med 2025;392:833-836.…

NEJM Interviews

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NEJM Interview: Peter Ubel on strategies for protecting patients from high out-of-pocket costs for drugs with questionable benefits. 6:55

16 hari yang lalu6:55

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Peter Ubel is a professor of business, public policy, and medicine at Duke University. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. P.A. Ubel, A. Grouls, and A.S. Kesselheim. Out of Pocket Getting Out of Hand — Reducing the Financial Toxicity of Rapidly Approved Drugs. N Engl J Med 2025;392:729-731.…

NEJM Interviews

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NEJM Interview: Yashaswini Singh on the expansion of private equity investments in health care and actions to safeguard patient interests in various countries. 11:58

23 hari yang lalu11:58

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Yashaswini Singh is an assistant professor of health services, policy, and practice at Brown University. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. Y. Singh, E. Fuse Brown, and I. Papanicolas. The Rise of Private Equity in Health Care — Not a Uniquely American Phenomenon. N Engl J Med 2025;392:627-629.…

NEJM Interviews

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NEJM Interview: Joseph Ross on the newly implemented Cell and Gene Therapy Access Model. 8:19

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Joseph Ross is a professor in the Department of Internal Medicine at the Yale School of Medicine and in the Department of Health Policy and Management at the Yale School of Public Health. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. J.S. Ross. Cell and Gene Therapies — Improving Access and Outcomes for Medicare and Medicaid Beneficiaries. N Engl J Med 2025;392:521-523.…

NEJM Interviews

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NEJM Interview: Daniel Aaron on a Supreme Court case about e-cigarettes that could have implications for the FDA’s authority and for public health. 9:22

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Daniel Aaron is an associate professor of law at the University of Utah S.J. Quinney College of Law. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. D.G. Aaron and C. Robertson. E-Cigarettes at the Supreme Court — Potential Implications for the FDA and Public Health. N Engl J Med 2025;392:417-419.…

NEJM Interviews

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NEJM Interview: Craig Spencer on the need for action to address persistent inequities in global health. 17:34

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Craig Spencer is an emergency medicine physician and an associate professor of the practice of health services, policy, and practice at the Brown University School of Public Health. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. C. Spencer. Ebola and a Decade of Disparities — Forging a Future for Global Health Equity. N Engl J Med 2025;392:313-315.…

NEJM Interviews

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NEJM Interview: Carmel Shachar on modernizing labor laws and strike regulations to support physicians, patients, and hospitals. 9:16

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Carmel Shachar is an assistant clinical professor of law and faculty director of the Health Law and Policy Clinic at Harvard Law School. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. T. Ramesh, C. Shachar, and H. Yu. Striking a Balance — Advancing Physician Collective-Bargaining Rights and Patient Protections. N Engl J Med 2025;392:209-211.…

NEJM Interviews

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NEJM Interview: David Velasquez on care for older, low-income adults who can’t enroll in Medicare or Medicaid because they’re undocumented immigrants. 11:35

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David Velasquez is an internal medicine resident physician at Brigham and Women's Hospital. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. D.E. Velasquez, E.T. Roberts, and J.F. Figueroa. The Plight of “Dual Noneligible” People in the United States. N Engl J Med 2025;392:105-107.…

NEJM Interviews

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NEJM Interview: Joey Mattingly on providing widespread access to HCV treatment at the lowest possible price. 12:16

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Joey Mattingly is an associate professor in the Department of Pharmacotherapy at the University of Utah College of Pharmacy. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. S.S. Tu, S. Kottilil, and T.J. Mattingly II. Leveraging Old Hepatitis C Therapies. N Engl J Med 2025;392:1-4.…

NEJM Interviews

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NEJM Interview: Lauren Schiff on the need for improved training and increased comfort in treating autistic people. 12:59

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Lauren Schiff is an associate professor of Ob/Gyn and a minimally invasive gynecologic surgeon at the University of North Carolina School of Medicine and the associate chief medical officer for quality and safety at UNC Hospitals. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. L.D. Schiff, A.O.D. Hester, and T. Benevides. Providing Effective Medical Care to Autistic People. N Engl J Med 2024;391:2281-2283.…

NEJM Interviews

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NEJM Interview: Bindu Kanapuru on the FDA’s new expedited withdrawal procedure for accelerated approvals. 9:12

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Bindu Kanapuru is a hematologist–oncologist physician in the Office of Oncologic Diseases at the FDA’s Center for Drug Evaluation and Research. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. B. Kanapuru and Others. Autopsy of a Drug Withdrawal — The Case of Melphalan Flufenamide. N Engl J Med 2024;391:2177-2179.…

NEJM Interviews

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NEJM Interview: Karen Joynt Maddox on the Transforming Episode Accountability Model recently announced by CMS. 11:16

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Karen Joynt Maddox is an associate professor of medicine at Washington University School of Medicine. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. S.A. Shashikumar, A.M. Ryan, and K.E. Joynt Maddox. Medicare’s New Mandatory Bundled-Payment Program — Are We Ready for TEAM? N Engl J Med 2024;391:2065-2067.…

NEJM Interviews

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NEJM Interview: Andrew Hantel on a source of discrimination against some patients in cancer research and care practices. 13:03

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Andrew Hantel is an assistant professor of medicine at Harvard Medical School and a faculty member in the Divisions of Leukemia and Population Sciences at Dana-Farber Cancer Institute and at the HMS Center for Bioethics. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. A. Hantel and Others. The Duffy Null Phenotype — Addressing a Source of Discrimination in Cancer Care. N Engl J Med 2024;391:1969-1972.…

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NEJM at AHA — Left Atrial Appendage Closure after Ablation for Atrial Fibrillation