How can we, humans, look at our relationship to nature differently? In season three of Going Wild, on top of stories about animals, we invite you to journey through the entire ecological web — from the tiniest of life forms to apex predators — alongside the scientists, activists and adventurers who study it. Wildlife biologist and host Dr. Rae Wynn-Grant has been studying wild animals in their natural habitats all over the world for years. Our award-winning podcast takes you inside the hidde ...
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Konten disediakan oleh Ryan Feldman and Ryan Feldman PharmD DABAT. Semua konten podcast termasuk episode, grafik, dan deskripsi podcast diunggah dan disediakan langsung oleh Ryan Feldman and Ryan Feldman PharmD DABAT atau mitra platform podcast mereka. Jika Anda yakin seseorang menggunakan karya berhak cipta Anda tanpa izin, Anda dapat mengikuti proses yang diuraikan di sini https://id.player.fm/legal.
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Mini Episode: Managing Crashing Hydroxychloroquine/Chloroquine OD
MP3•Beranda episode
Manage episode 337597523 series 3382933
Konten disediakan oleh Ryan Feldman and Ryan Feldman PharmD DABAT. Semua konten podcast termasuk episode, grafik, dan deskripsi podcast diunggah dan disediakan langsung oleh Ryan Feldman and Ryan Feldman PharmD DABAT atau mitra platform podcast mereka. Jika Anda yakin seseorang menggunakan karya berhak cipta Anda tanpa izin, Anda dapat mengikuti proses yang diuraikan di sini https://id.player.fm/legal.
Quick review
- Toxic dose
- Chloroquine >5g severe toxicity is expected (toxicity may develop below this)
- HCQ less well defind
- Clinical effects
- Seizures (sodium channel blockade)
- Arrhythmia (sodium channel blockade)
- Hypotension (Alpha blockade)
- Hypokalemia
- Management
- Activated Charcoal if awake and alert and no risk of emesis
- Early invasive supportive care based on the following retrospective case control series https://www.nejm.org/doi/full/10.1056/NEJM198801073180101
- High dose epinephrine (0.25 mcg/kg/min)
- Diazepam 1-2 mg/kg over 30 minutes followed by 1-2 mg/kg over 24 hours (seizure prevention)
- Evidence supports this may be cardio protective as well
- Early intubation
- Consultation with poison center recommended 1-800-222-1222
56 episode
MP3•Beranda episode
Manage episode 337597523 series 3382933
Konten disediakan oleh Ryan Feldman and Ryan Feldman PharmD DABAT. Semua konten podcast termasuk episode, grafik, dan deskripsi podcast diunggah dan disediakan langsung oleh Ryan Feldman and Ryan Feldman PharmD DABAT atau mitra platform podcast mereka. Jika Anda yakin seseorang menggunakan karya berhak cipta Anda tanpa izin, Anda dapat mengikuti proses yang diuraikan di sini https://id.player.fm/legal.
Quick review
- Toxic dose
- Chloroquine >5g severe toxicity is expected (toxicity may develop below this)
- HCQ less well defind
- Clinical effects
- Seizures (sodium channel blockade)
- Arrhythmia (sodium channel blockade)
- Hypotension (Alpha blockade)
- Hypokalemia
- Management
- Activated Charcoal if awake and alert and no risk of emesis
- Early invasive supportive care based on the following retrospective case control series https://www.nejm.org/doi/full/10.1056/NEJM198801073180101
- High dose epinephrine (0.25 mcg/kg/min)
- Diazepam 1-2 mg/kg over 30 minutes followed by 1-2 mg/kg over 24 hours (seizure prevention)
- Evidence supports this may be cardio protective as well
- Early intubation
- Consultation with poison center recommended 1-800-222-1222
56 episode
Semua episode
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