Goal – Deliver Cancer Drugs Faster: Dr. Marie-Agnès Doucey, Calico Biosystems

X-Health.show - meet the future of healthcare

Do you know what is the % of cancer drug candidates that fail in human trials?
Guess, and I bet you underestimated it.
This is what we speak at the beginning of this episode and what my guest wants to change dramatically.
You will also hear about:

• the % of patients that actually benefit from approved cancer drug therapies (spoiler: so so low)
• cancer monotherapies vs. cancer combination therapies
• how to reproduce the human cancer ecosystem from a tumor
• precision oncology
• multiomics analysis
• and how to bring cancer drugs faster to patients

Dr. Marie-Agnès Doucey, the co-founder of Calico Biosystems, is a biotechnology engineer with a PhD in biochemistry. She has over 15 years of experience in R&D and drug development programs in oncology.
Calico Biosystems is a Swiss startup developing a drug testing platform that uses patients’ tumors, multiomics profiling, and computational modeling to predict the clinical efficacy of anti-cancer drugs at the pre-clinical stage. Radically accelerating drug development.
Here is their website:
https://calicobiosystems.com/
0:00 Dr. Marie-Agnès Doucey and Calico Biosystems
1:15 Why Only 10% of Cancer Patients Benefit from Therapies
9:00 Complexity of Experimental Oncology
12:50 Cancer Monotherapies vs. Cancer Combination Therapies
15:11 How to Reproduce Human Cancer Ecosystem
17:10 What is Precision Oncology
20:35 Platform for Cancer Drug Developers Instead of Animal Models
32:34 Collaboration with the University of Lausanne
37:49 What is Multiomics Analysis
40:35 De-risking Clinical Studies and Moving to the Clinical Stage
47:16 More Than a Decade of Research to Found a Startup
53:07 Thank You, Follow Calico Biosystems
53:55 Follow X-Health.show, Disclaimer
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Chapter

1. Dr. Marie-Agnès Doucey and Calico Biosystems (00:00:00)

2. Why Only 10% of Cancer Patients Benefit from Therapies (00:01:15)

3. Complexity of Experimental Oncology (00:09:00)

4. Cancer Monotherapies vs. Cancer Combination Therapies (00:12:50)

5. How to Reproduce Human Cancer Ecosystem (00:15:11)

6. What is Precision Oncology (00:17:10)

7. Platform for Cancer Drug Developers Instead of Animal Models (00:20:35)

8. Collaboration with the University of Lausanne (00:32:34)

9. What is Multiomics Analysis (00:37:49)

10. De-risking Clinical Studies and Moving to the Clinical Stage (00:40:35)

11. More Than a Decade of Research to Found a Startup (00:47:16)

12. Thank You, Follow Calico Biosystems (00:53:07)

13. Follow X-Health.show, Disclaimer (00:53:55)