#443: Kevin Klatt, PhD, RD - Can Choline Help Improve DHA Status?

Sigma Nutrition Radio

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2y ago 1:11:19

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A recently published study by Klatt and colleagues examined the impact of choline supplementation alongside DHA supplementation, versus DHA supplementation alone, on DHA status in pregnancy. It is known that DHA is a critical nutrient at this time for healthy development of the child. And through a number of mechanisms discussed later, it has been hypothesized that choline could lead to greater DHA status. We discuss:

What is the connection between choline and DHA? What is the PEMT pathway?
Study design for the choline + DHA trial
Are there risks of high-dose choline?
Main findings of the trial
How DHA status is not just a function of DHA intake, but also methyl metabolism too
Issues with omega-3 trials; e.g. not taking baseline status into account
Pragmatic recommendations for health professionals and patients
Different forms of choline supplements
Choline supplementation vs. food-derived choline

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